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Gabapentin/B-complex
Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, while B-complex vitamins support neuronal metabolism and myelin formation.
Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, while B-complex vitamins support neuronal metabolism and myelin formation. Used for Neuropathic pain (peripheral neuropathy, diabetic neuropathy), Postherpetic neuralgia, Adjunctive therapy for partial seizures.
At a glance
| Generic name | Gabapentin/B-complex |
|---|---|
| Also known as | Gavindo® |
| Sponsor | Merck KGaA, Darmstadt, Germany |
| Drug class | Anticonvulsant/analgesic combination with vitamin supplementation |
| Target | Alpha-2-delta subunit of voltage-gated calcium channels (gabapentin component) |
| Modality | Small molecule |
| Therapeutic area | Neurology; Pain Management |
| Phase | FDA-approved |
Mechanism of action
Gabapentin is an anticonvulsant and analgesic that decreases calcium influx into neurons, reducing the release of excitatory neurotransmitters and thereby suppressing abnormal neuronal firing. The B-complex vitamins (typically B1, B6, B12) provide essential cofactors for nerve function, energy metabolism, and myelin synthesis, complementing gabapentin's mechanism to support peripheral nerve health and reduce neuropathic pain.
Approved indications
- Neuropathic pain (peripheral neuropathy, diabetic neuropathy)
- Postherpetic neuralgia
- Adjunctive therapy for partial seizures
Common side effects
- Dizziness
- Somnolence
- Ataxia
- Fatigue
- Peripheral edema
- Tremor
Key clinical trials
- A Controlled Clinical Trial Assessing the Efficacy of Vitamin B Prophylaxis in Attenuating Paclitaxel-induced Neuropathy and the Imperative Use of Gabapentin in Diabetic Ovarian Cancer Patients and the Potential Effect on Disease Response. (NA)
- The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient (PHASE2, PHASE3)
- Use of Preoperative Gabapentin in Patients Undergoing Laparoscopic Cholecystectomy
- Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |