{"id":"gabapentin-b-complex","safety":{"commonSideEffects":[{"rate":"17-28","effect":"Dizziness"},{"rate":"21-27","effect":"Somnolence"},{"rate":"13-15","effect":"Ataxia"},{"rate":"11-18","effect":"Fatigue"},{"rate":"7-8","effect":"Peripheral edema"},{"rate":"6-9","effect":"Tremor"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gabapentin is an anticonvulsant and analgesic that decreases calcium influx into neurons, reducing the release of excitatory neurotransmitters and thereby suppressing abnormal neuronal firing. The B-complex vitamins (typically B1, B6, B12) provide essential cofactors for nerve function, energy metabolism, and myelin synthesis, complementing gabapentin's mechanism to support peripheral nerve health and reduce neuropathic pain.","oneSentence":"Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, while B-complex vitamins support neuronal metabolism and myelin formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:40:32.975Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain (peripheral neuropathy, diabetic neuropathy)"},{"name":"Postherpetic neuralgia"},{"name":"Adjunctive therapy for partial seizures"}]},"trialDetails":[{"nctId":"NCT07191587","phase":"NA","title":"A Controlled Clinical Trial Assessing the Efficacy of Vitamin B Prophylaxis in Attenuating Paclitaxel-induced Neuropathy and the Imperative Use of Gabapentin in Diabetic Ovarian Cancer Patients and the Potential Effect on Disease Response.","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2024-12-01","conditions":"Peripheral Neuropathy, Chemotherapy-induced, Disease Management","enrollment":146},{"nctId":"NCT04689971","phase":"PHASE2, PHASE3","title":"The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient","status":"UNKNOWN","sponsor":"Duta Wacana Christian University","startDate":"2020-11-03","conditions":"Painful Diabetic Neuropathy","enrollment":60},{"nctId":"NCT03583892","phase":"","title":"Use of Preoperative Gabapentin in Patients Undergoing Laparoscopic Cholecystectomy","status":"UNKNOWN","sponsor":"Centro Hospitalar do Porto","startDate":"2018-07-01","conditions":"Pain, Postoperative","enrollment":60},{"nctId":"NCT01364298","phase":"PHASE4","title":"Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2011-04","conditions":"Diabetic Peripheral Neuropathic Pain","enrollment":353}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Gavindo®"],"phase":"marketed","status":"active","brandName":"Gabapentin/B-complex","genericName":"Gabapentin/B-complex","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, while B-complex vitamins support neuronal metabolism and myelin formation. Used for Neuropathic pain (peripheral neuropathy, diabetic neuropathy), Postherpetic neuralgia, Adjunctive therapy for partial seizures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}