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Interferon beta-1a (Rebif)
Interferon beta-1a (Rebif) is a Interferon beta Small molecule drug developed by Merck KGaA, Darmstadt, Germany. It is currently FDA-approved for Relapsing-remitting multiple sclerosis, Clinically isolated syndrome with MRI features consistent with multiple sclerosis. Also known as: Rebif New Formulation, Rebif.
Interferon beta-1a activates interferon signaling pathways to modulate immune responses and reduce inflammatory activity in the central nervous system.
Interferon beta-1a (Rebif) is used to treat multiple sclerosis, specifically relapsing-remitting multiple sclerosis. It is administered as part of a treatment regimen that includes the use of RebiSmart, a device designed to improve treatment adherence.
At a glance
| Generic name | Interferon beta-1a (Rebif) |
|---|---|
| Also known as | Rebif New Formulation, Rebif |
| Sponsor | Merck KGaA, Darmstadt, Germany |
| Drug class | Interferon beta |
| Target | Interferon-beta receptor (IFNAR) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Neurology |
| Phase | FDA-approved |
Mechanism of action
Interferon beta-1a binds to interferon-beta receptors on immune cells and oligodendrocytes, triggering JAK-STAT signaling that increases expression of anti-inflammatory genes and reduces pro-inflammatory cytokine production. This leads to decreased migration of immune cells across the blood-brain barrier and reduced demyelination in multiple sclerosis. The drug also enhances natural killer cell activity and promotes a shift toward a more regulatory immune phenotype.
Approved indications
- Relapsing-remitting multiple sclerosis
- Clinically isolated syndrome with MRI features consistent with multiple sclerosis
Common side effects
- Injection site reactions
- Flu-like symptoms (fever, chills, myalgia)
- Headache
- Fatigue
- Depression
- Elevated liver enzymes
- Leukopenia
Key clinical trials
- An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Third Trimester in Finland and Sweden
- Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS (PHASE3)
- Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis (PHASE3)
- Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial (NA)
- A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis (PHASE3)
- Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS (PHASE4)
- Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
- Phase 3 Efficacy and Safety Study of BG00012 in Pediatric Subjects With Relapsing-remitting Multiple Sclerosis (RRMS) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Interferon beta-1a (Rebif) CI brief — competitive landscape report
- Interferon beta-1a (Rebif) updates RSS · CI watch RSS
- Merck KGaA, Darmstadt, Germany portfolio CI
Frequently asked questions about Interferon beta-1a (Rebif)
What is Interferon beta-1a (Rebif)?
How does Interferon beta-1a (Rebif) work?
What is Interferon beta-1a (Rebif) used for?
Who makes Interferon beta-1a (Rebif)?
Is Interferon beta-1a (Rebif) also known as anything else?
What drug class is Interferon beta-1a (Rebif) in?
What development phase is Interferon beta-1a (Rebif) in?
What are the side effects of Interferon beta-1a (Rebif)?
What does Interferon beta-1a (Rebif) target?
Related
- Drug class: All Interferon beta drugs
- Target: All drugs targeting Interferon-beta receptor (IFNAR)
- Manufacturer: Merck KGaA, Darmstadt, Germany — full pipeline
- Therapeutic area: All drugs in Immunology / Neurology
- Indication: Drugs for Relapsing-remitting multiple sclerosis
- Indication: Drugs for Clinically isolated syndrome with MRI features consistent with multiple sclerosis
- Also known as: Rebif New Formulation, Rebif
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing