Amsterdam UMC, location VUmc

Quick facts

Marketed products

• Benzbromaron · Ophthalmology
• Change in daily dosage of Growth Hormone · Endocrinology
  Growth hormone replacement therapy restores physiological growth hormone levels to promote normal growth, metabolism, and body composition.
• dexamethason · Other
• Discontinuation of imipenem-cilastatin or meropenem
• ertugliflozine · Other
• Ferricarboxymaltose · Other
• GnRHa
• Inotropes · Other
• Lipiodol UltraFluid · Oncology
  Lipiodol UltraFluid is an iodized poppy seed oil contrast agent that accumulates in hepatic lesions and provides both diagnostic imaging and therapeutic embolization.
• Lopinavir/ritonavir + nevirapine · Infectious Disease / Virology
  This combination inhibits HIV protease (lopinavir/ritonavir) and reverse transcriptase (nevirapine) to suppress viral replication.
• Lopinavir/ritonavir + zidovudine + lamivudine · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase and protease to suppress viral replication.
• Macrogol Only Product in Oral Dose Form · Gastroenterology
  Macrogol is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements.
• Magnesium hydroxide 724mg
• Placebo (for rivastigmine) · Neurology
  Placebo has no active pharmacological mechanism; it is an inert substance used as a control in clinical trials.
• Psyllium Orange · Gastroenterology
  Psyllium is a soluble dietary fiber that absorbs water in the gastrointestinal tract to increase stool bulk and promote bowel regularity.
• Standard interval dosing
  Standard interval dosing is a dosing schedule approach rather than a drug itself, referring to the administration of medications at regular, fixed time intervals.

Phase 3 pipeline

• Exenatide infusion · Diabetes
  Exenatide is a GLP-1 receptor agonist that mimics glucagon-like peptide-1 to stimulate insulin secretion and reduce blood glucose in response to meals.
• Radium-223 chloride · Oncology
  Radium-223 is an alpha-emitting radioisotope that mimics calcium and selectively targets bone metastases, delivering high-energy alpha particles directly to cancer cells in bone.
• Rhenium-188-HEDP · Oncology
  Rhenium-188-HEDP is a radiopharmaceutical that localizes to areas of increased bone metabolism and delivers beta radiation directly to bone lesions for pain palliation and potential therapeutic benefit.

Phase 2 pipeline

• Afatinib, Osimertinib, Carboplatin and Pemetrexed · Oncology
  Afatinib and Osimertinib are irreversible tyrosine kinase inhibitors targeting the epidermal growth factor receptor (EGFR), while Carboplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, and Pemetrexed is an antifolate drug that inhibits thymidylate synthase.
• AZD0530 Difumarate · Oncology
  AZD0530 is a Src family kinase inhibitor that blocks intracellular signaling pathways involved in cell proliferation and survival.
• Intrathecal Baclofen Pump · Neurology
  GABA_B receptor agonist
• nivolumab-daratumumab
• Paclitaxel-trastzumab

Phase 1 pipeline

• [18F]F-AraG PET imaging
• [89Zr]Zr-Df-Crefmirlimab PET imaging
• Aminobiphosphonate · Other
• Cripec Docetaxel
• Everolimus plus Exemestane
• GLP-1 receptor antagonist
• Iloprost infusion
• insulin glargine treatment
• Liraglutide treatment 12 weeks
• Metamucil Orange
• Modulation of FiO2
• Prednisolone and Exenatide
• Volcolon sugar free

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Amsterdam UMC, location VUmc portfolio CI brief
• Amsterdam UMC, location VUmc pipeline updates RSS