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Macrogol Only Product in Oral Dose Form
Macrogol Only Product in Oral Dose Form is a Osmotic laxative Small molecule drug developed by Amsterdam UMC, location VUmc. It is currently FDA-approved for Constipation (chronic and acute), Bowel preparation prior to diagnostic procedures. Also known as: Macrogol/electrolytes.
Macrogol is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements.
Macrogol is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements. Used for Constipation (chronic and acute), Bowel preparation prior to diagnostic procedures.
At a glance
| Generic name | Macrogol Only Product in Oral Dose Form |
|---|---|
| Also known as | Macrogol/electrolytes |
| Sponsor | Amsterdam UMC, location VUmc |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Macrogol (polyethylene glycol) is a non-absorbable polymer that creates an osmotic gradient in the colon, increasing stool water content and facilitating defecation. It works locally in the gastrointestinal tract without systemic absorption, making it suitable for chronic use in constipation management.
Approved indications
- Constipation (chronic and acute)
- Bowel preparation prior to diagnostic procedures
Common side effects
- Abdominal bloating
- Abdominal discomfort
- Nausea
- Flatulence
Key clinical trials
- Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants (PHASE3)
- Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour (PHASE3)
- Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations (PHASE2)
- Prevention of Opioid-induced Constipation in Patients With Advanced Cancer (PHASE4)
- A Phase IIb Study to Evaluate a Long-Acting Intramuscular Regimen for Maintenance of Virologic Suppression (Following Induction With an Oral Regimen of GSK1265744 and Abacavir/Lamivudine) in Human Immunodeficiency Virus Type 1 (HIV-1) Infected, Antiretroviral Therapy-Naive Adult Subjects (PHASE2)
- To Assess Safety, Tolerability and Pharmacokinetics of BI 730357 in Healthy Male Volunteers (PHASE1)
- Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy (PHASE4)
- Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Macrogol Only Product in Oral Dose Form CI brief — competitive landscape report
- Macrogol Only Product in Oral Dose Form updates RSS · CI watch RSS
- Amsterdam UMC, location VUmc portfolio CI
Frequently asked questions about Macrogol Only Product in Oral Dose Form
What is Macrogol Only Product in Oral Dose Form?
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Related
- Drug class: All Osmotic laxative drugs
- Manufacturer: Amsterdam UMC, location VUmc — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Constipation (chronic and acute)
- Indication: Drugs for Bowel preparation prior to diagnostic procedures
- Also known as: Macrogol/electrolytes
- Compare: Macrogol Only Product in Oral Dose Form vs similar drugs
- Pricing: Macrogol Only Product in Oral Dose Form cost, discount & access