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Change in daily dosage of Growth Hormone
Change in daily dosage of Growth Hormone is a Growth hormone replacement therapy Small molecule drug developed by Amsterdam UMC, location VUmc. It is currently FDA-approved for Growth hormone deficiency in children, Growth hormone deficiency in adults, Short stature due to growth hormone insufficiency. Also known as: Change in daily dosage of Somatropin.
Growth hormone replacement therapy restores physiological growth hormone levels to promote normal growth, metabolism, and body composition.
Growth hormone replacement therapy restores physiological growth hormone levels to promote normal growth, metabolism, and body composition. Used for Growth hormone deficiency in children, Growth hormone deficiency in adults, Short stature due to growth hormone insufficiency.
At a glance
| Generic name | Change in daily dosage of Growth Hormone |
|---|---|
| Also known as | Change in daily dosage of Somatropin |
| Sponsor | Amsterdam UMC, location VUmc |
| Drug class | Growth hormone replacement therapy |
| Target | Growth hormone receptor (GHR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Growth hormone (somatotropin) is a peptide hormone that binds to growth hormone receptors on target tissues, stimulating insulin-like growth factor-1 (IGF-1) production and promoting protein synthesis, lipolysis, and linear growth. Dosage adjustments are made to achieve optimal therapeutic levels while minimizing adverse effects. This is a marketed therapy used to treat growth hormone deficiency in both pediatric and adult populations.
Approved indications
- Growth hormone deficiency in children
- Growth hormone deficiency in adults
- Short stature due to growth hormone insufficiency
Common side effects
- Injection site reactions
- Headache
- Hyperglycemia
- Carpal tunnel syndrome
- Fluid retention
- Arthralgia
Key clinical trials
- Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation (EARLY_PHASE1)
- Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT) (PHASE2)
- Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia (PHASE3)
- Progesterone-modified Natural Cycle for FET (PHASE3)
- Evaluate the Efficacy and Safety Growth Hormone, Glutamine and Diet in Patients With Short Bowel Syndrome (SBS) (PHASE4)
- A Study of Bevacizumab (Avastin) in Combination With Neoadjuvant Treatment Regimens in Participants With Primary Human Epidermal Growth Factor Receptor 2 (HER2) Negative Breast Cancer (PHASE2)
- Safety and Efficacy Study of MOD-4023 to Treat Children With Growth Hormone Deficiency (PHASE3)
- The Effect of Blood Flow Restriction With and Without Arginine on Physical Performance and Growth Hormone (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Change in daily dosage of Growth Hormone CI brief — competitive landscape report
- Change in daily dosage of Growth Hormone updates RSS · CI watch RSS
- Amsterdam UMC, location VUmc portfolio CI
Frequently asked questions about Change in daily dosage of Growth Hormone
What is Change in daily dosage of Growth Hormone?
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Related
- Drug class: All Growth hormone replacement therapy drugs
- Target: All drugs targeting Growth hormone receptor (GHR)
- Manufacturer: Amsterdam UMC, location VUmc — full pipeline
- Therapeutic area: All drugs in Endocrinology
- Indication: Drugs for Growth hormone deficiency in children
- Indication: Drugs for Growth hormone deficiency in adults
- Indication: Drugs for Short stature due to growth hormone insufficiency
- Also known as: Change in daily dosage of Somatropin
- Compare: Change in daily dosage of Growth Hormone vs similar drugs
- Pricing: Change in daily dosage of Growth Hormone cost, discount & access