{"id":"change-in-daily-dosage-of-growth-hormone","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Carpal tunnel syndrome"},{"rate":null,"effect":"Fluid retention"},{"rate":null,"effect":"Arthralgia"}]},"_chembl":{"chemblId":"CHEMBL2108078","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Growth hormone (somatotropin) is a peptide hormone that binds to growth hormone receptors on target tissues, stimulating insulin-like growth factor-1 (IGF-1) production and promoting protein synthesis, lipolysis, and linear growth. Dosage adjustments are made to achieve optimal therapeutic levels while minimizing adverse effects. 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Hardin-Baylor","startDate":"2019-09-04","conditions":"Blood Flow Restriction, Growth Hormone, Strength Outcomes","enrollment":30},{"nctId":"NCT00766038","phase":"PHASE2","title":"Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury.","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2008-09","conditions":"Traumatic Brain Injury","enrollment":63},{"nctId":"NCT02311894","phase":"PHASE4","title":"A Post-Marketing Study of the Immunogenicity of Somatropin (Ribosomal Deoxyribo Nucleic Acid [rDNA] Origin) Injection (Nutropin AQ®) in Children With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Genentech, Inc.","startDate":"2015-03-31","conditions":"Growth Hormone Deficiency","enrollment":82},{"nctId":"NCT01007071","phase":"PHASE3","title":"Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults With Growth Hormone Deficiency","status":"COMPLETED","sponsor":"Stanford University","startDate":"2009-11-01","conditions":"Hypopituitarism","enrollment":11},{"nctId":"NCT00140413","phase":"PHASE4","title":"Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia","status":"COMPLETED","sponsor":"Children's Hospital Los Angeles","startDate":"2004-12","conditions":"Growth Hormone Deficiency, Septo-Optic Dysplasia, Hypopituitarism","enrollment":20},{"nctId":"NCT02006836","phase":"NA","title":"Glycemic Responses to Majia Pomelos in Type 2 Diabetic Patients","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2013-01","conditions":"Diabetes","enrollment":59},{"nctId":"NCT01877512","phase":"PHASE4","title":"GH and Cardiovascular Risk Factors","status":"COMPLETED","sponsor":"Amsterdam UMC, location VUmc","startDate":"2013-05","conditions":"Growth Hormone Deficiency, Cardiovascular Diseases, Metabolic Syndrome","enrollment":32},{"nctId":"NCT00163215","phase":"PHASE3","title":"Growth 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Used for Growth hormone deficiency in children, Growth hormone deficiency in adults, Short stature due to growth hormone insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}