Tricyclic antidepressant

This page covers all Tricyclic antidepressant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Norepinephrine transporter (NET), Serotonin transporter (SERT), Adenosine receptor A3, Sodium-dependent dopamine transporter.

Targets

Norepinephrine transporter (NET), Serotonin transporter (SERT) · Adenosine receptor A3 · Sodium-dependent dopamine transporter · Sodium-dependent noradrenaline transporter · Sodium-dependent serotonin transporter · Histamine H1 receptor

Marketed (12)

• TCA treatment · Radboud University Medical Center · Psychiatry / Neurology
  TCA treatment refers to tricyclic antidepressant therapy, which blocks the reuptake of norepinephrine and serotonin at neuronal synapses to increase their availability in the central nervous system.
• Triptil · Neuroscience
• Norpramin · Validus Pharms · Metabolic
• Aventyl · Neuroscience
• Tofranil · Neuroscience
• Zonalon · Immunology
  Zonalon works by blocking histamine H1 receptors in the brain, which helps to reduce anxiety and itching, and improve mood.
• Surmontil · Teva Womens · Neuroscience
• TCA · Nova Scotia Health Authority · Psychiatry, Pain Management
  TCA inhibits the reuptake of norepinephrine and serotonin in the central nervous system, increasing their synaptic availability.
• Standard Preparation · University of California, Irvine · Psychiatry
  This drug works by inhibiting the reuptake of norepinephrine, serotonin, and dopamine.
• Anafranil · Specgx Llc · Neuroscience
• Aventyl · Neuroscience
• Endep · AstraZeneca · Neuroscience

Phase 3 pipeline (1)

• doxepin solution · Nanfang Hospital, Southern Medical University · Psychiatry
  Doxepin solution is a tricyclic antidepressant that works by inhibiting the reuptake of serotonin and norepinephrine.