Triazole antifungal
This page covers all Triazole antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Fungal cytochrome P450 lanosterol 14α-demethylase (CYP51), Fungal cytochrome P450 14α-demethylase (CYP51), Lanosterol 14α-demethylase (CYP51).
Targets
Fungal cytochrome P450 lanosterol 14α-demethylase (CYP51) · Fungal cytochrome P450 14α-demethylase (CYP51) · Lanosterol 14α-demethylase (CYP51) · Fungal CYP51 (lanosterol 14α-demethylase) · Cytochrome P450 14α-demethylase (CYP51) · Fungal cytochrome P450 (lanosterol 14α-demethylase) · Lanosterol 14α-demethylase
Marketed (9)
- fast itraconazole tablet · University of Maryland, Baltimore · Infectious Disease
Itraconazole is a triazole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - slow itraconazole tablet · University of Maryland, Baltimore · Infectious Disease
Slow itraconazole tablet is a modified-release formulation of itraconazole that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in fungal cell membranes. - Posaconazole Delayed Release Oral Tablet · Cedars-Sinai Medical Center · Infectious Disease
Posaconazole inhibits fungal cell membrane synthesis by blocking lanosterol 14α-demethylase, a key enzyme in ergosterol production. - Voriconazole low dose · Manjunath Prakash Pai · Infectious Disease
Voriconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - medium itraconazole tablet · University of Maryland, Baltimore · Infectious Disease
Itraconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis and compromising fungal cell membrane integrity. - Vfend (voriconazole) tablet · Seoul National University Hospital · Infectious Disease
Voriconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - Voriconazole clinical practice · Instituto de Investigación Hospital Universitario La Paz · Infectious Disease
Voriconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - Voriconazole high dose · Manjunath Prakash Pai · Infectious Disease
Voriconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - Diflucan (fluconazole) · Pfizer · Infectious Disease
Fluconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis and compromising fungal cell membrane integrity.
Phase 3 pipeline (7)
- Diflucan IV, oral · Pfizer · Infectious Disease
Diflucan (fluconazole) inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - Intrastromal voriconazole · University of California, San Francisco · Ophthalmology / Infectious Disease
Intrastromal voriconazole is an antifungal agent delivered directly into the corneal stroma to treat fungal keratitis by inhibiting fungal cell wall synthesis. - ITCZ-IV · Janssen Pharmaceutical K.K. · Infectious Disease
ITCZ-IV is an intravenous formulation of itraconazole, a triazole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - Fluconazole capsule · Jiangsu HengRui Medicine Co., Ltd. · Infectious Disease
Fluconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. - WHO-recommended SOC Itraconazole · University of Minnesota · Infectious Diseases
Itraconazole inhibits the synthesis of ergosterol, an essential component of fungal cell membranes. - Posaconazole oral suspension · Merck Sharp & Dohme LLC · Infectious Disease
Posaconazole inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting fungal cell wall integrity. - Efinaconazole Topical · Western University of Health Sciences · Dermatology / Infectious Disease
Efinaconazole is a triazole antifungal that inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in fungal cell membranes.
Phase 2 pipeline (1)
- Bifonazole spray twice daily · Bayer · Dermatology
Bifonazole is an antifungal agent that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.