What are Topical local anesthetic drugs?

Topical local anesthetic drugs are pharmacologic agents that share a common mechanism (typically targeting Voltage-gated sodium channels). 3 are currently marketed, with 2 more in clinical development.

What are the marketed Topical local anesthetic drugs?

Marketed Topical local anesthetic drugs include TAC alternate gel, Synera(TM), Anesthetic Topical Adhesive Synera.

Topical local anesthetic

3 marketed 2 in Phase 3

This page covers all Topical local anesthetic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Voltage-gated sodium channels.

Targets

Voltage-gated sodium channels

Marketed (3)

TAC alternate gel · The University of Texas Health Science Center, Houston · Pain management / Emergency medicine
TAC alternate gel is a topical anesthetic formulation combining lidocaine, prilocaine, and other agents to provide local pain relief and numbing at the site of application.
Synera(TM) · IWK Health Centre · Dermatology/Pain Management
Synera is a topical anesthetic patch that combines lidocaine and tetracaine to provide rapid local anesthesia through transdermal delivery.
Anesthetic Topical Adhesive Synera · Brown, Theodore R., M.D., MPH · Anesthesia/Pain Management
Synera is a topical anesthetic patch that delivers lidocaine and tetracaine through the skin to numb the area before minor procedures.

Phase 3 pipeline (2)

Promescent Lidocaine Spray · Eugene Y Rhee, MD · Urology / Sexual Health
Lidocaine spray topically anesthetizes nerve endings in penile tissue to reduce sensory stimulation and delay ejaculation.
EMLA Topical Product · American University of Beirut Medical Center · Dermatology / Pain Management
EMLA is a topical anesthetic cream containing lidocaine and prilocaine that blocks sodium channels in nerve fibers to produce local anesthesia and analgesia.