What are S1P receptor modulator drugs?

S1P receptor modulator drugs are pharmacologic agents that share a common mechanism (typically targeting S1P1). 1 are currently marketed, with 19 more in clinical development.

What are the marketed S1P receptor modulator drugs?

Marketed S1P receptor modulator drugs include Group S+T.

S1P receptor modulator

1 marketed 13 in Phase 3 6 in Phase 2

This page covers all S1P receptor modulator drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting S1P1, S1PR1, S1P receptor.

Targets

S1P1 · S1PR1 · S1P receptor · S1P1, S1P3, S1P4, S1P5, S1P6

Marketed (1)

Group S+T · Huazhong University of Science and Technology · Immunology
This drug targets the S1P receptor to modulate lymphocyte trafficking and reduce inflammation.

Phase 3 pipeline (13)

NPC-16 Standard Dosing Regimen Group · Nobelpharma · Immunology
NPC-16 is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1) to modulate immune responses.
SPM 962 · Otsuka Pharmaceutical Co., Ltd. · Autoimmune diseases
SPM 962 is a selective, high-affinity, and orally bioavailable small molecule inhibitor of the sphingosine-1-phosphate receptor 1 (S1PR1).
RPC1063 · Celgene · Oncology
RPC1063 is a sphingosine 1-phosphate receptor modulator.
TVP-1012 · Takeda · Autoimmune diseases
TVP-1012 is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1).
GP404141 · Geropharm · Immunology
GP404141 is a small molecule drug that targets the S1P receptor.
RO0503821 (1x/4 Weeks) · Hoffmann-La Roche · Immunology
RO0503821 is a small molecule that targets the S1P1 receptor.
Elizaria® · AO GENERIUM · Multiple Sclerosis
Elizaria is a small molecule that targets the S1P1 receptor.
Aplause® · Phytopharm Consulting Brazil · Immunology
Aplause is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1) to modulate immune responses.
allo-APZ2-OTS · RHEACELL GmbH & Co. KG · Autoimmune diseases
Allo-APZ2-OTS is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1).
Standard of Care IST · Biogen · Neurology
IST is a disease-modifying therapy that targets the immune system to slow disease progression in multiple sclerosis.
zilucoplan (RA101495) · UCB Biopharma SRL · Immunology
Zilucoplan is a sphingosine 1-phosphate receptor modulator.
Fp MDPI · Teva Branded Pharmaceutical Products R&D, Inc. · Immunology
Fp MDPI is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1) to modulate immune cell trafficking.
NPC-16 Continuous Dosing Regimen Group · Nobelpharma · Immunology
NPC-16 is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1) to modulate immune cell trafficking.

Phase 2 pipeline (6)

BOL-303242-X · Bausch & Lomb Incorporated · Ophthalmology
BOL-303242-X is a small molecule that targets the S1P1 receptor.
Comp03 · Promius Pharma, LLC · Multiple sclerosis
Comp03 is a small molecule that targets the S1P receptor.
GSK1521498 · GlaxoSmithKline · Autoimmune diseases
GSK1521498 is a small molecule drug that targets the S1P1 receptor.
ABT-894 · AbbVie (prior sponsor, Abbott) · Multiple Sclerosis, Autoimmune Diseases
ABT-894 is a small molecule that targets the sphingosine-1-phosphate receptor 1 (S1PR1).
ACT01 · Promius Pharma, LLC · Multiple Sclerosis
ACT01 is a small molecule that targets the S1P receptor.
AD 337 · Sosei · Autoimmune diseases
AD 337 is a small molecule targeting the S1P1 receptor.