What are Recombinant enzyme drugs?

Recombinant enzyme drugs are pharmacologic agents that share a common mechanism (typically targeting Extracellular DNA). 5 are currently marketed, with 4 more in clinical development.

What are the marketed Recombinant enzyme drugs?

Marketed Recombinant enzyme drugs include Pulmozyme®, Dornase alfa (Pulmozyme), recAP, rhDNAse, DNase.

Recombinant enzyme

5 marketed 2 in Phase 3 2 in Phase 2

This page covers all Recombinant enzyme drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Extracellular DNA, Extracellular DNA (deoxyribonucleic acid), Lipopolysaccharide (LPS) and pathogen-associated molecular patterns (PAMPs).

Targets

Extracellular DNA · Extracellular DNA (deoxyribonucleic acid) · Lipopolysaccharide (LPS) and pathogen-associated molecular patterns (PAMPs) · Deoxyribonucleic acid (DNA)

Marketed (5)

Pulmozyme® · AO GENERIUM · Pulmonology / Respiratory
Pulmozyme is a recombinant human DNase that breaks down extracellular DNA in airway secretions to reduce mucus viscosity and improve lung function.
Dornase alfa (Pulmozyme) · University of Jena · Pulmonology / Respiratory
Dornase alfa is a recombinant human deoxyribonuclease that cleaves extracellular DNA in airway secretions, reducing mucus viscosity and improving clearance in cystic fibrosis lungs.
recAP · AM-Pharma · Immunology / Gastroenterology / Critical Care
recAP is a recombinant alkaline phosphatase that breaks down lipopolysaccharide (LPS) and other inflammatory mediators to reduce systemic inflammation.
rhDNAse · The Hospital for Sick Children · Respiratory / Pulmonary
rhDNAse is a recombinant human deoxyribonuclease that breaks down extracellular DNA in airway secretions to reduce mucus viscosity.
DNase · The Hospital for Sick Children · Respiratory / Pulmonary
DNase is a recombinant deoxyribonuclease enzyme that breaks down extracellular DNA in viscous secretions, reducing mucus viscosity and improving airway clearance.

Phase 3 pipeline (2)

Dornase Alfa Inhalant Solution [Pulmozyme] · University Hospital, Strasbourg, France · Pulmonology / Respiratory
Dornase alfa is a recombinant human deoxyribonuclease that cleaves extracellular DNA in airway secretions, reducing mucus viscosity and improving clearance.
Dornase Alfa Inhalation Solution · University of Missouri-Columbia · Pulmonology / Respiratory
Dornase alfa is a recombinant human deoxyribonuclease that cleaves extracellular DNA in airway secretions to reduce mucus viscosity and improve clearance.

Phase 2 pipeline (2)

Daily infusion of dornase alfa · Fondation Ophtalmologique Adolphe de Rothschild · Pulmonary/Respiratory
Dornase alfa is a recombinant human DNase that breaks down extracellular DNA in mucus to reduce viscosity and improve clearance.
AIR DNase · Protalix · Respiratory / Pulmonary
AIR DNase is a recombinant human deoxyribonuclease that degrades extracellular DNA to reduce mucus viscosity and improve airway clearance in cystic fibrosis.