Extracellular DNA — Drug Target

All drugs that target Extracellular DNA — marketed and clinical-stage. Includes 1 drug classes acting on this target.

Drug classes

Recombinant enzyme

Marketed (1)

• Pulmozyme® · AO GENERIUM · Recombinant enzyme · Pulmonology / Respiratory
  Pulmozyme is a recombinant human DNase that breaks down extracellular DNA in airway secretions to reduce mucus viscosity and improve lung function.

Phase 2 pipeline (2)

• Daily infusion of dornase alfa · Fondation Ophtalmologique Adolphe de Rothschild · Recombinant enzyme · Pulmonary/Respiratory
  Dornase alfa is a recombinant human DNase that breaks down extracellular DNA in mucus to reduce viscosity and improve clearance.
• AIR DNase · Protalix · Recombinant enzyme · Respiratory / Pulmonary
  AIR DNase is a recombinant human deoxyribonuclease that degrades extracellular DNA to reduce mucus viscosity and improve airway clearance in cystic fibrosis.