Azole antifungal

This page covers all Azole antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Fungal cytochrome P450 (lanosterol 14α-demethylase), Lanosterol 14α-demethylase (CYP51), Squalene epoxidase (fungal).

Targets

Fungal cytochrome P450 (lanosterol 14α-demethylase) · Lanosterol 14α-demethylase (CYP51) · Squalene epoxidase (fungal) · Thromboxane-A synthase · ATP-binding cassette sub-family G member 2 · Cytochrome P450 2C19 · Lanosterol 14α-demethylase · Fungal lanosterol 14α-demethylase (CYP51) · Fungal CYP51 (lanosterol 14α-demethylase) · 14-alpha-demethylase

Marketed (8)

• FLUCON® · Military Hospital of Tunis · Infectious Disease
  FLUCON® is an azole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane.
• Terconazole Vaginal Suppository · Hatem AbuHashim · Infectious Disease
  Terconazole inhibits fungal cell membrane synthesis by blocking lanosterol 14α-demethylase, disrupting ergosterol production in Candida species.
• Jublia® · Dong-A ST Co., Ltd. · Dermatology / Infectious Disease
  Jublia is a topical antifungal that inhibits fungal squalene epoxidase, disrupting ergosterol synthesis in the fungal cell membrane.
• Clotrimazole Troche · Weill Medical College of Cornell University · Infectious Disease
  Clotrimazole inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting membrane integrity and causing fungal cell death.
• Spectazole · Cardiovascular
  Spectazole works by inhibiting the enzyme lanosterol 14α-demethylase, which is necessary for fungal cells to produce ergosterol, a critical component of their cell membranes.
• Femstat 3 · Bayer · Infectious Disease
• Cresemba · Astellas Pharma · Infectious Disease
  Isavuconazonium sulfate is a prodrug that converts to isavuconazole, an azole antifungal.
• Exelderm · Journey · Cardiovascular

Phase 3 pipeline (5)

• Vfend - voriconazole · Pfizer · Infectious Diseases
  Voriconazole is an antifungal medication that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
• VFEND® I.V., Oral · Pfizer · Infectious Disease
  VFEND® I.V., Oral is an antifungal medication that inhibits the synthesis of ergosterol, an essential component of fungal cell membranes.
• Oteseconazole (VT-1161) · Mycovia Pharmaceuticals Inc. · Infectious Disease
  Oteseconazole is a selective inhibitor of fungal lanosterol 14α-demethylase (CYP51) that disrupts ergosterol synthesis in fungal cell membranes.
• voriconazole (VFEND®) · Pfizer · Infectious Diseases
  Voriconazole is an antifungal medication that inhibits the synthesis of ergosterol, an essential component of fungal cell membranes.
• ITCZ Oral Solution · Janssen Pharmaceutical K.K. · Infectious Disease
  ITCZ (itraconazole) is an azole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane.

Phase 2 pipeline (4)

• Clotrimazole troches · Hadassah Medical Organization · Infectious Disease
  Clotrimazole troches work by inhibiting fungal ergosterol synthesis, disrupting the fungal cell membrane and causing cell death.
• Antifungal Comparator · Elion Therapeutics, Inc. · Infectious Disease
  Antifungal mechanism involves inhibiting fungal cell wall synthesis
• Bifonazole spray once daily · Bayer · Infectious Diseases
  Bifonazole is an antifungal agent that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
• Ketoconazole tablet · Purdue Pharma LP · Infectious Disease
  Ketoconazole is a broad-spectrum antifungal agent that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes, by blocking the cytochrome P450-dependent enzyme lanosterol 14α-demethylase.

Phase 1 pipeline (2)

• AB-106, Itraconazole · Nuvation Bio Inc. · Infectious Disease
  Inhibits fungal cytochrome P450 14α-demethylase
• ASK120067;itraconazole · Jiangsu Aosaikang Pharmaceutical Co., Ltd. · Infectious Disease
  Azole antifungal agent