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Spectazole (ECONAZOLE)
Spectazole works by inhibiting the enzyme lanosterol 14α-demethylase, which is necessary for fungal cells to produce ergosterol, a critical component of their cell membranes.
At a glance
| Generic name | ECONAZOLE |
|---|---|
| Sponsor | Alvogen |
| Drug class | Azole Antifungal |
| Target | Thromboxane-A synthase |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
| First approval | 1982 |
Mechanism of action
Ecoza topical foam is an azole antifungal see Clinical Pharmacology (12.4).
Approved indications
- Candidiasis of skin
- Pityriasis versicolor
- Tinea corporis
- Tinea cruris
- Tinea pedis
Common side effects
- Burning
- Itching
- Stinging
- Erythema
Key clinical trials
- Efficacy of Self Vs. Physician Application of Triamcinolone-Econazole in Otomycosis (PHASE4)
- Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea Pedis (PHASE3)
- A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail (PHASE2)
- Tolerability and Pharmacokinetic Study of Econazole Nitrate and Benzydamine HCl Intravaginal Cream (PHASE1)
- Tolerability and Pharmacokinetic Study of Econazole Nitrate Plus Benzydamine HCl Vaginal Pessary (PHASE1)
- Safety and Efficacy of Econazole Nitrate Foam 1% in Subjects With Tinea Pedis (PHASE3)
- A Study of Econazole Foam 1% in Athlete's Foot (PHASE2)
- Comparative PK Study of Econazole Nitrate Foam and Econazole Nitrate Cream in Subjects With Interdigital Tinea Pedis Aged 12 Years to Less Than 18 Years (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |