Antimetabolite

This page covers all Antimetabolite drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Ribonucleotide reductase, Thymidylate synthase; RNA and DNA incorporation, DNA polymerase.

Targets

Ribonucleotide reductase · Thymidylate synthase; RNA and DNA incorporation · DNA polymerase · Thymidylate synthase · Dihydrofolate reductase

Marketed (6)

• Hydroxy Urea · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Oncology
  Hydroxyurea inhibits ribonucleotide reductase, an enzyme essential for DNA synthesis, leading to cell cycle arrest and apoptosis in rapidly dividing cells.
• 5-fluoro-uracil · UNICANCER · Oncology
  5-fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cell death.
• Cytarabine · Nippon Shinyaku Co., Ltd. · Oncology
  Cytarabine inhibits DNA polymerase and incorporates into DNA/RNA, killing cells in S-phase.
• Fluorouracil Injection · Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Oncology
  Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.
• 5Fluorouracil · University of Nebraska · Oncology
  5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.
• 5-Fluouracil · Hoffmann-La Roche · Oncology
  5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.

Phase 3 pipeline (13)

• low dose capecitabine · Lund University Hospital · Oncology
  Capecitabine is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase and disrupts DNA synthesis in cancer cells.
• methotrexate prefilled syringe · medac GmbH · Oncology, Autoimmune diseases
  Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, disrupting DNA synthesis and cell division.
• Tegafur-uracil (UFT) · Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group · Oncology
  Tegafur-uracil (UFT) is a prodrug that is metabolized into 5-fluorouracil (5-FU), which then inhibits thymidylate synthase.
• 5-Flurouracil · Janssen Research & Development, LLC · Oncology
  5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cell death.
• Fluorouracil/Adrucil · Bristol-Myers Squibb · Oncology
  Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.
• 5-Fluoruracil · Grupo Espanol Multidisciplinario del Cancer Digestivo · Oncology
  5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.
• S-1 Chemotherapy · Asan Medical Center · Oncology
  S-1 is a chemotherapy medication that works by inhibiting thymidylate synthase, thereby disrupting DNA synthesis and cell division.
• Fluorouracil (5FU) · University of Chicago · Oncology
  Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.
• Methotrexate - Delay · University Hospital, Montpellier · Oncology, Immunology, Rheumatology
  Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, disrupting DNA synthesis and cell division.
• Fluorouracil (5-FU) · EMD Serono Research & Development Institute, Inc. · Oncology
  Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cancer cell death.
• S-1 therapy · The First Affiliated Hospital with Nanjing Medical University · Oncology
  S-1 therapy is a chemotherapy medication that works by inhibiting thymidylate synthase, thereby preventing DNA synthesis and cell division.
• UFT, Calcium Folinate · Iwate Medical University · Oncology
  UFT is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase, leading to DNA damage and cell death.
• TEGAFUR URACIL - FOLINIC ACID · Centre Oscar Lambret · Oncology
  Tegafur uracil combined with folinic acid enhances the cytotoxic effects of 5-fluorouracil by increasing its intracellular concentration and prolonging its action.

Phase 2 pipeline (4)

• ARM C FOLFIRI · GERCOR - Multidisciplinary Oncology Cooperative Group · Oncology
  Inhibits thymidylate synthase
• CAPOX 6 month · NRG Oncology · Oncology
  Capecitabine is a thymidylate synthase inhibitor.
• CAPOX 3 month · NRG Oncology · Oncology
  Capecitabine is a thymidylate synthase inhibitor.
• Capecitabine during all Radiotherapy period · Grupo Espanol Multidisciplinario del Cancer Digestivo · Oncology
  Capecitabine is a thymidylate synthase inhibitor.