What drugs target Dihydrofolate reductase?

8+ drugs target Dihydrofolate reductase, including Wellcovorin, Klaron, Gentamicin, Trimethoprim.

What drug classes act on Dihydrofolate reductase?

Drug classes acting on Dihydrofolate reductase include Folate Analog, Sulfonamide Antibacterial, gentamicin, Sulfonamide Antimicrobial [EPC], Antimetabolite.

Dihydrofolate reductase — Drug Target

8 drugs 4 marketed 3 in Phase 3

All drugs that target Dihydrofolate reductase — marketed and clinical-stage. Includes 7 drug classes acting on this target.

Drug classes

Folate Analog · Sulfonamide Antibacterial · gentamicin · Sulfonamide Antimicrobial [EPC] · Antimetabolite · Antifolate · aminopterin

Marketed (4)

Wellcovorin · Pfizer Japan Inc · Folate Analog · Oncology
Klaron · Merck & Co. · Sulfonamide Antibacterial · Infectious Disease
Gentamicin · Merck & Co. · gentamicin · Immunology
Trimethoprim · Dr Reddys Labs Sa · Sulfonamide Antimicrobial [EPC] · Immunology

Phase 3 pipeline (3)

methotrexate prefilled syringe · medac GmbH · Antimetabolite · Oncology, Autoimmune diseases
Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, disrupting DNA synthesis and cell division.
USEL/Leucovorin · Hokkaido Gastrointestinal Cancer Study Group · Antifolate · Oncology
Leucovorin is a folate analog that inhibits the enzyme dihydrofolate reductase, which is involved in DNA synthesis and repair.
Methotrexate - Delay · University Hospital, Montpellier · Antimetabolite · Oncology, Immunology, Rheumatology
Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, disrupting DNA synthesis and cell division.