Antimalarial combination

This page covers all Antimalarial combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Malaria parasite (Plasmodium) hemoglobin metabolism and mitochondrial function, Plasmodium dihydrofolate reductase, dihydropteroate synthase, and hemozoin formation, Plasmodium falciparum heme and mitochondrial function.

Targets

Malaria parasite (Plasmodium) hemoglobin metabolism and mitochondrial function · Plasmodium dihydrofolate reductase, dihydropteroate synthase, and hemozoin formation · Plasmodium falciparum heme and mitochondrial function · Plasmodium DNA/protein synthesis; dihydrofolate reductase; dihydropteroate synthase · Plasmodium falciparum heme metabolism and parasite membranes · Dihydrofolate reductase (chlorproguanil/dapsone); mitochondrial function (artesunate) · Plasmodium falciparum heme iron (artesunate); parasite digestive vacuole and mitochondria (mefloquine) · Plasmodium falciparum and Plasmodium vivax (parasite species); mechanism involves multiple targets including mitochondrial function and heme detoxification · Parasite heme polymerase (mefloquine); parasite proteins and lipids (dihydroartemisinin); hemozoin (piperaquine) · Mitochondrial electron transport chain (atovaquone); dihydrofolate reductase (proguanil)

Marketed (29)

• lumefantrine-artemether · Centers for Disease Control and Prevention · Infectious Disease
  Lumefantrine and artemether are antimalarial agents that work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and generating reactive oxygen species.
• Amodiaquine plus sulphadoxine-pyrimethamine combination · Centre for Global Health Research, Ghana · Infectious Disease
  This combination inhibits parasite DNA synthesis and folate metabolism through two complementary antimalarial agents that work synergistically against Plasmodium parasites.
• Artemether, Lumefantrine Drug Combination · University of Yaounde 1 · Infectious Disease
  Artemether and lumefantrine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and causing oxidative damage.
• Quinine plus sulfadoxine-pyrimethamine · Albert Schweitzer Hospital · Infectious Disease
  This combination uses quinine to inhibit parasite protein synthesis and sulfadoxine-pyrimethamine to block folate metabolism in malaria parasites, providing synergistic antimalarial activity.
• artemether-lumefantrine (ALN) · Jhpiego · Infectious Disease
  Artemether and lumefantrine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and causing rapid parasite clearance.
• chlorproguanil-dapsone plus artesunate · Centers for Disease Control and Prevention · Infectious Disease
  This combination antimalarial drug works by inhibiting parasite dihydrofolate reductase (via chlorproguanil and dapsone) and disrupting mitochondrial function (via artesunate) to kill Plasmodium parasites through multiple pathways.
• artesunate and mefloquine · Mepha Ltd. · Infectious Disease
  Artesunate and mefloquine work synergistically to kill malaria parasites through distinct mechanisms: artesunate generates reactive oxygen species that damage parasite proteins and organelles, while mefloquine disrupts parasite digestive vacuole function and mitochondrial activity.
• Tafenoquine plus Artesunate-pyronaridine · Menzies School of Health Research · Infectious Disease
  This combination targets malaria parasites through two complementary mechanisms: tafenoquine eliminates dormant liver-stage parasites and gametocytes, while artesunate-pyronaridine rapidly kills blood-stage parasites.
• Mefloquine and Dihydroartemisinin-piperaquine · University of Oxford · Infectious Disease
  This combination antimalarial works by disrupting parasite blood-stage development through multiple mechanisms: mefloquine inhibits heme polymerization in the parasite digestive vacuole, while dihydroartemisinin-piperaquine generates reactive oxygen species and inhibits parasite protein synthesis.
• Atovaquone / Proguanil · Radboud University Medical Center · Infectious Disease
  Atovaquone inhibits parasite mitochondrial electron transport while proguanil inhibits dihydrofolate reductase, together disrupting nucleotide synthesis and energy production in malaria parasites.
• Artesunate + Sulfadoxine-Pyrimethamine · Sanofi · Infectious Disease
  Artesunate kills malaria parasites by generating reactive oxygen species, while sulfadoxine-pyrimethamine inhibits folate synthesis in the parasite, providing synergistic antimalarial activity.
• Pyronaridine artesunate · Medicines for Malaria Venture · Infectious Disease
  Pyronaridine artesunate is a fixed-dose combination antimalarial that kills malaria parasites through dual mechanisms: pyronaridine intercalates into parasite DNA while artesunate generates reactive oxygen species that damage parasite structures.
• Tafenoquine plus DHA-Piperaquine · Menzies School of Health Research · Infectious Disease
  This combination uses tafenoquine to eliminate dormant malaria parasites in the liver and piperaquine (in DHA-piperaquine) to kill active blood-stage parasites, providing both curative and preventive antimalarial activity.
• Artemether + Lumefantrine · GlaxoSmithKline · Infectious Disease
  Artemether and lumefantrine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and causing oxidative damage.
• Chloroquine + Primaquine · U.S. Army Medical Research and Development Command · Infectious Disease
  Chloroquine and primaquine work together as antimalarial agents by interfering with parasite DNA and disrupting the parasite's ability to metabolize hemoglobin.
• artemisinin/naphthoquine · Ifakara Health Institute · Infectious Disease
  Artemisinin acts as an antimalarial by generating reactive oxygen species that damage parasite proteins and membranes, while naphthoquine inhibits parasite heme polymerization and electron transport.
• amodiaquine-artesunate versus amodiaquine · Charite University, Berlin, Germany · Infectious Disease
  Amodiaquine-artesunate is a fixed-dose combination antimalarial that combines a quinoline derivative with a fast-acting artemisinin to kill malaria parasites through multiple mechanisms.
• Artesunate + Amodiaquine · Professor Anders Björkman · Infectious Disease
  Artesunate and amodiaquine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and interfering with their DNA replication.
• Artesunate-amodiaquine fixed-dose combination · Epicentre · Infectious Disease
  Artesunate and amodiaquine work synergistically to kill malaria parasites by generating reactive oxygen species and disrupting parasite metabolism.
• Artesunate + Mefloquine · Armed Forces Research Institute of Medical Sciences, Thailand · Infectious Disease
  Artesunate kills malaria parasites by generating reactive oxygen species that damage parasite proteins and membranes, while mefloquine inhibits parasite heme polymerization and disrupts mitochondrial function.
• Artesunate/mefloquine (AS/MQ) · Armed Forces Research Institute of Medical Sciences, Thailand · Infectious Disease
  Artesunate and mefloquine are antimalarial agents that work synergistically to kill malaria parasites through distinct mechanisms: artesunate generates reactive oxygen species that damage parasite proteins and DNA, while mefloquine disrupts parasite membrane function and metabolism.
• Artesunate and Pyronaridine · Armed Forces Research Institute of Medical Sciences, Thailand · Infectious Disease
  Artesunate and pyronaridine are antimalarial agents that work synergistically to kill malaria parasites by generating reactive oxygen species and disrupting parasite metabolism.
• AA(FDC) · Medecins Sans Frontieres, Netherlands · Infectious Disease
  AA(FDC) is a fixed-dose combination antimalarial therapy containing artesunate and amodiaquine that works by disrupting parasite metabolism and preventing malaria infection.
• artesunate-lapdap · London School of Hygiene and Tropical Medicine · Infectious Disease
  Artesunate-lapdap is a fixed-dose combination that combines an artemisinin derivative with a diaminopyrimidine antifolate to kill malaria parasites through complementary mechanisms.
• Sulfadoxine-pyrimethamine plus artesunate · London School of Hygiene and Tropical Medicine · Infectious Disease
  This combination drug kills malaria parasites by inhibiting their folate metabolism (sulfadoxine-pyrimethamine) and disrupting their mitochondrial function (artesunate).
• amodiaquine plus sulfadoxine-pyrimethamine · Centers for Disease Control and Prevention · Infectious Disease
  This combination inhibits parasite DNA synthesis and folate metabolism through complementary antimalarial mechanisms.
• arthemether + lumefantrine · Sanofi · Infectious Disease
  Artemether and lumefantrine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and interfering with their DNA replication.
• Atovaquone Proguanil and Artesunate Pyronaridine · Armed Forces Research Institute of Medical Sciences, Thailand · Infectious Disease
  This combination drug uses atovaquone-proguanil to inhibit parasite mitochondrial function and pyronaridine-artesunate to generate reactive oxygen species and inhibit heme polymerization, together targeting multiple stages of malaria parasite development.
• Mefloquine- Artesunate · Centers for Disease Control and Prevention · Infectious Disease
  Mefloquine and artesunate work synergistically to kill malaria parasites through distinct mechanisms: mefloquine disrupts parasite membrane function while artesunate generates reactive oxygen species that damage parasite proteins and DNA.

Phase 3 pipeline (4)

• Arthemeter-lumefantrine · Research Institute for Tropical Medicine, Philippines · Infectious Disease
  Artemether and lumefantrine work synergistically to kill malaria parasites by disrupting their hemoglobin metabolism and causing oxidative damage.
• Amodiaquine+Sulfadoxine/Pyrimethamine · University of California, San Francisco · Infectious Disease
  This combination drug inhibits parasite dihydrofolate reductase and dihydropteroate synthase enzymes while disrupting parasite hemoglobin metabolism to treat malaria.
• AQ + artesunate · London School of Hygiene and Tropical Medicine · Infectious Disease
  AQ (amodiaquine) and artesunate work synergistically to kill malaria parasites by generating reactive oxygen species and disrupting parasite metabolism.
• CQ coadministered with PQ · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado · Infectious Disease
  CQ (chloroquine) and PQ (primaquine) work together as antimalarial agents that disrupt parasite metabolism and eliminate both blood and tissue stages of Plasmodium infection.