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Amodiaquine+Sulfadoxine/Pyrimethamine
Amodiaquine+Sulfadoxine/Pyrimethamine is a Antimalarial combination Small molecule drug developed by University of California, San Francisco. It is currently in Phase 3 development for Uncomplicated Plasmodium falciparum malaria, Malaria treatment in endemic regions.
This combination drug inhibits parasite dihydrofolate reductase and dihydropteroate synthase enzymes while disrupting parasite hemoglobin metabolism to treat malaria.
This combination drug inhibits parasite dihydrofolate reductase and dihydropteroate synthase enzymes while disrupting parasite hemoglobin metabolism to treat malaria. Used for Uncomplicated Plasmodium falciparum malaria, Malaria treatment in endemic regions.
At a glance
| Generic name | Amodiaquine+Sulfadoxine/Pyrimethamine |
|---|---|
| Sponsor | University of California, San Francisco |
| Drug class | Antimalarial combination |
| Target | Parasite dihydrofolate reductase, dihydropteroate synthase, hemoglobin metabolism |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Amodiaquine is a 4-aminoquinoline that disrupts malaria parasite hemoglobin digestion and generates reactive oxygen species. Sulfadoxine/Pyrimethamine is a fixed-dose combination that inhibits sequential steps in parasite folate synthesis, blocking dihydropteroate synthase and dihydrofolate reductase. Together, these agents provide synergistic antimalarial activity through complementary mechanisms.
Approved indications
- Uncomplicated Plasmodium falciparum malaria
- Malaria treatment in endemic regions
Common side effects
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Pruritus
- Stevens-Johnson syndrome (rare)
Key clinical trials
- Perennial Malaria Chemoprevention in the Malaria Vaccine Era (PHASE4)
- Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi (PHASE4)
- Parasite Clearance and Protection from Infection (PCPI) in Cameroon (PHASE3)
- Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women (PHASE3)
- Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal (PHASE4)
- Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study (PHASE3)
- Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) (PHASE4)
- Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Amodiaquine+Sulfadoxine/Pyrimethamine CI brief — competitive landscape report
- Amodiaquine+Sulfadoxine/Pyrimethamine updates RSS · CI watch RSS
- University of California, San Francisco portfolio CI
Frequently asked questions about Amodiaquine+Sulfadoxine/Pyrimethamine
What is Amodiaquine+Sulfadoxine/Pyrimethamine?
How does Amodiaquine+Sulfadoxine/Pyrimethamine work?
What is Amodiaquine+Sulfadoxine/Pyrimethamine used for?
Who makes Amodiaquine+Sulfadoxine/Pyrimethamine?
What drug class is Amodiaquine+Sulfadoxine/Pyrimethamine in?
What development phase is Amodiaquine+Sulfadoxine/Pyrimethamine in?
What are the side effects of Amodiaquine+Sulfadoxine/Pyrimethamine?
What does Amodiaquine+Sulfadoxine/Pyrimethamine target?
Related
- Drug class: All Antimalarial combination drugs
- Target: All drugs targeting Parasite dihydrofolate reductase, dihydropteroate synthase, hemoglobin metabolism
- Manufacturer: University of California, San Francisco — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Uncomplicated Plasmodium falciparum malaria
- Indication: Drugs for Malaria treatment in endemic regions
- Compare: Amodiaquine+Sulfadoxine/Pyrimethamine vs similar drugs
- Pricing: Amodiaquine+Sulfadoxine/Pyrimethamine cost, discount & access