{"id":"amodiaquine-sulfadoxine-pyrimethamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL3137690","moleculeType":"Unknown","molecularWeight":"559.05"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amodiaquine is a 4-aminoquinoline that disrupts malaria parasite hemoglobin digestion and generates reactive oxygen species. Sulfadoxine/Pyrimethamine is a fixed-dose combination that inhibits sequential steps in parasite folate synthesis, blocking dihydropteroate synthase and dihydrofolate reductase. Together, these agents provide synergistic antimalarial activity through complementary mechanisms.","oneSentence":"This combination drug inhibits parasite dihydrofolate reductase and dihydropteroate synthase enzymes while disrupting parasite hemoglobin metabolism to treat malaria.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:28.601Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated Plasmodium falciparum malaria"},{"name":"Malaria treatment in endemic regions"}]},"trialDetails":[{"nctId":"NCT07322068","phase":"PHASE4","title":"Perennial Malaria Chemoprevention in the Malaria Vaccine Era","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-09","conditions":"Malaria, Falciparum","enrollment":1290},{"nctId":"NCT06083688","phase":"PHASE4","title":"Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi","status":"ACTIVE_NOT_RECRUITING","sponsor":"Liverpool School of Tropical Medicine","startDate":"2024-10-14","conditions":"Malaria,Falciparum, Anemia in Children","enrollment":1000},{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT00131703","phase":"PHASE3","title":"Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-03","conditions":"Malaria, Pregnancy","enrollment":900},{"nctId":"NCT06225297","phase":"PHASE4","title":"Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal","status":"SUSPENDED","sponsor":"PATH","startDate":"2024-01-19","conditions":"Malaria","enrollment":4600},{"nctId":"NCT04319380","phase":"PHASE3","title":"Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2020-04-01","conditions":"Malaria,Falciparum, Child, Only","enrollment":5098},{"nctId":"NCT03178643","phase":"PHASE4","title":"Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-01-23","conditions":"Malaria,Falciparum","enrollment":246},{"nctId":"NCT06337253","phase":"PHASE4","title":"Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique","status":"NOT_YET_RECRUITING","sponsor":"Malaria Consortium","startDate":"2024-03-26","conditions":"Malaria,Falciparum, Chemoprevention","enrollment":1000},{"nctId":"NCT05471544","phase":"PHASE3","title":"Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-18","conditions":"Malaria","enrollment":3575},{"nctId":"NCT00852371","phase":"PHASE3","title":"Intermittent Preventive Treatment of Malaria in Schoolchildren","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-02","conditions":"Malaria, Intermittent Preventive Treatment","enrollment":780},{"nctId":"NCT06182176","phase":"NA","title":"Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-05-27","conditions":"Malaria, Soil Transmitted Helminths, Schistosomiasis","enrollment":1200},{"nctId":"NCT05946642","phase":"PHASE3","title":"Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2023-07-15","conditions":"Malaria","enrollment":13000},{"nctId":"NCT05186363","phase":"PHASE4","title":"Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-01-08","conditions":"Malaria","enrollment":3156},{"nctId":"NCT05323721","phase":"PHASE4","title":"Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-06-01","conditions":"Malaria","enrollment":6805},{"nctId":"NCT05478954","phase":"PHASE4","title":"Chemoprevention Efficacy Study in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-15","conditions":"Malaria","enrollment":800},{"nctId":"NCT04969185","phase":"","title":"Association Between Drug Levels, Malaria, and Antimalarial Resistance in the Setting of Seasonal Malaria Chemoprevention","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2021-08-16","conditions":"Malaria,Falciparum","enrollment":310},{"nctId":"NCT05979896","phase":"PHASE4","title":"Chemoprevention Efficacy Study Nigeria","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2023-07-28","conditions":"Malaria","enrollment":800},{"nctId":"NCT04149106","phase":"PHASE3","title":"Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin","status":"UNKNOWN","sponsor":"University Clinical Research Center, Mali","startDate":"2019-07-01","conditions":"Malaria,Falciparum","enrollment":4556},{"nctId":"NCT05354258","phase":"NA","title":"Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2022-06-16","conditions":"Malaria, Soil Transmitted Helminths, Schistosomiasis","enrollment":600},{"nctId":"NCT03143218","phase":"PHASE3","title":"Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2017-04-17","conditions":"Malaria,Falciparum, Children, Only","enrollment":5920},{"nctId":"NCT05081089","phase":"PHASE2","title":"Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2021-10-12","conditions":"Malaria,Falciparum","enrollment":80},{"nctId":"NCT00123552","phase":"PHASE3","title":"Longitudinal Antimalarial Combinations in Uganda","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2004-11","conditions":"Malaria","enrollment":601},{"nctId":"NCT02646410","phase":"NA","title":"Optimization of Seasonal Malaria Chemoprevention (SMC) Delivery","status":"UNKNOWN","sponsor":"University of Bamako","startDate":"2014-08","conditions":"Malaria, Anemia","enrollment":10000},{"nctId":"NCT02211729","phase":"PHASE3","title":"A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2014-05","conditions":"Malaria, Respiratory Infections","enrollment":22090},{"nctId":"NCT00376155","phase":"PHASE4","title":"Comparison of Two Strategies for the Delivery of IPTc","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2006-05","conditions":"Malaria","enrollment":14000},{"nctId":"NCT03035305","phase":"NA","title":"Seasonal Malaria Chemoprevention With or Without Lipid-based Nutrient Supplement in Children Aged 6-59 Months in Mali","status":"COMPLETED","sponsor":"Alliance for International Medical Action","startDate":"2016-08","conditions":"Malaria","enrollment":36717},{"nctId":"NCT00561899","phase":"PHASE2, PHASE3","title":"Comparison of Three Drug Combinations for Intermittent Treatment of Malaria in Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-08","conditions":"Malaria","enrollment":1295},{"nctId":"NCT00944840","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTc) and Home Based Management of Malaria (HMM)in The Gambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-09","conditions":"Malaria","enrollment":1312},{"nctId":"NCT00146718","phase":"PHASE2, PHASE3","title":"Anti-Malarial Drug Resistance in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-08","conditions":"Malaria","enrollment":755},{"nctId":"NCT00146783","phase":"PHASE2, PHASE3","title":"Navrongo Drug Options for IPT in Pregnancy Trial","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2004-06","conditions":"Malaria","enrollment":3642},{"nctId":"NCT00158548","phase":"PHASE3","title":"ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2001-06","conditions":"Malaria, Falciparum Malaria, Vivax Malaria","enrollment":650},{"nctId":"NCT00132548","phase":"PHASE3","title":"A Trial of Four Drug Regimens for the Prevention of Malaria in Senegalese Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2004-06","conditions":"Malaria","enrollment":2200},{"nctId":"NCT00119132","phase":"PHASE2, PHASE3","title":"Effectiveness of Intermittent Preventive Treatment for Malaria in Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2005-06","conditions":"Malaria","enrollment":2602},{"nctId":"NCT02831023","phase":"PHASE2","title":"Phase 2 Efficacy Study of Primaquine and Methylene Blue","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-07","conditions":"Malaria","enrollment":80},{"nctId":"NCT00323622","phase":"PHASE2","title":"Long-Term Follow-up of Children for a 2-Year Period to Confirm the Safety and Immunogenicity of GSK 257049 Vaccine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2005-04","conditions":"Malaria","enrollment":1737},{"nctId":"NCT00432367","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-02","conditions":"Malaria, Anaemia, Pregnancy","enrollment":3333},{"nctId":"NCT02894294","phase":"","title":"Evaluation of Seasonal Malaria Chemoprevention in Kita","status":"COMPLETED","sponsor":"University of Bamako","startDate":"2014-07","conditions":"Malaria, Anemia","enrollment":1162},{"nctId":"NCT01651416","phase":"PHASE4","title":"Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana","status":"COMPLETED","sponsor":"Centre for Global Health Research, Ghana","startDate":"2012-07","conditions":"Malaria, Anaemia","enrollment":2400},{"nctId":"NCT01319448","phase":"PHASE1, PHASE2","title":"Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2011-09","conditions":"Malaria, Sickle Cell Crisis","enrollment":270},{"nctId":"NCT01634945","phase":"NA","title":"Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire","status":"COMPLETED","sponsor":"Swiss Federal Institute of Technology","startDate":"2012-04","conditions":"Anemia","enrollment":629},{"nctId":"NCT00111163","phase":"NA","title":"Intermittent Preventive Treatment With Antimalarials in Kenyan Infants","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2004-03","conditions":"Malaria, Anemia","enrollment":1516},{"nctId":"NCT00164710","phase":"PHASE4","title":"Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2005-04","conditions":"Malaria, Falciparum","enrollment":365},{"nctId":"NCT01449045","phase":"PHASE3","title":"Trial of Malaria Seasonal IPTc Combined With Community Case Management","status":"COMPLETED","sponsor":"Cheikh Anta Diop University, Senegal","startDate":"2011-07","conditions":"Malaria","enrollment":4554},{"nctId":"NCT01454752","phase":"NA","title":"Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and Cognition","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2011-11","conditions":"Malaria, Anaemia","enrollment":860},{"nctId":"NCT01328990","phase":"PHASE1, PHASE2","title":"Pharmacokinetics of Sulfadoxine-pyrimethamine Plus Amodiaquine for Intermittent Preventive Treatment in Children (IPTc)","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2011-04","conditions":"Malaria","enrollment":150},{"nctId":"NCT00285662","phase":"NA","title":"Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants","status":"COMPLETED","sponsor":"Papua New Guinea Institute of Medical Research","startDate":"2006-06","conditions":"Malaria, Anemia","enrollment":1100},{"nctId":"NCT00941785","phase":"PHASE2, PHASE3","title":"Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2009-07","conditions":"Malaria","enrollment":1500},{"nctId":"NCT00738946","phase":"NA","title":"A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-08","conditions":"Malaria","enrollment":6000},{"nctId":"NCT00529620","phase":"PHASE3","title":"Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-09","conditions":"Malaria","enrollment":1833},{"nctId":"NCT00712374","phase":"PHASE4","title":"Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-09","conditions":"Malaria","enrollment":100000},{"nctId":"NCT00460369","phase":"NA","title":"Treatment of Uncomplicated Malaria in Benin","status":"COMPLETED","sponsor":"Institut de Recherche pour le Developpement","startDate":"2007-04","conditions":"Uncomplicated Malaria","enrollment":240},{"nctId":"NCT00461578","phase":"NA","title":"Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2005-04","conditions":"Malaria","enrollment":800},{"nctId":"NCT00127998","phase":"NA","title":"Antimalarial Drug Resistance in Mali","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2005-07","conditions":"Malaria","enrollment":1011},{"nctId":"NCT00118807","phase":"PHASE3","title":"Trial of the Effectiveness of AQ/AS, SP/AQ and SP/CQ for Uncomplicated Malaria in Gambian Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-08","conditions":"Malaria","enrollment":1800}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":45,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Amodiaquine+Sulfadoxine/Pyrimethamine","genericName":"Amodiaquine+Sulfadoxine/Pyrimethamine","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination drug inhibits parasite dihydrofolate reductase and dihydropteroate synthase enzymes while disrupting parasite hemoglobin metabolism to treat malaria. Used for Uncomplicated Plasmodium falciparum malaria, Malaria treatment in endemic regions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}