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Artesunate-amodiaquine fixed-dose combination
Artesunate-amodiaquine fixed-dose combination is a Antimalarial combination Small molecule drug developed by Epicentre. It is currently FDA-approved for Uncomplicated malaria caused by Plasmodium falciparum, Malaria caused by Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. Also known as: AS-AQ Winthrop® Sanofi Aventis.
Artesunate and amodiaquine work synergistically to kill malaria parasites by generating reactive oxygen species and disrupting parasite metabolism.
Artesunate and amodiaquine work synergistically to kill malaria parasites by generating reactive oxygen species and disrupting parasite metabolism. Used for Uncomplicated malaria caused by Plasmodium falciparum, Malaria caused by Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae.
At a glance
| Generic name | Artesunate-amodiaquine fixed-dose combination |
|---|---|
| Also known as | AS-AQ Winthrop® Sanofi Aventis |
| Sponsor | Epicentre |
| Drug class | Antimalarial combination |
| Target | Plasmodium falciparum (multiple parasite targets) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Artesunate, a semi-synthetic artemisinin derivative, generates free radicals that damage parasite proteins and membranes. Amodiaquine, a 4-aminoquinoline, inhibits parasite heme detoxification and disrupts DNA synthesis. The combination provides rapid parasite clearance and reduces the risk of resistance development.
Approved indications
- Uncomplicated malaria caused by Plasmodium falciparum
- Malaria caused by Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae
Common side effects
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Diarrhea
- Pruritus
Key clinical trials
- Health Systems Implementation and Molecular Surveillance of Multiple First-Line Treatments for Uncomplicated Malaria in Western Kenya
- A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines (PHASE3)
- A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs. (PHASE3)
- Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19 (PHASE2)
- A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia) (PHASE3)
- Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali (PHASE1)
- Methylene Blue Against Falciparum Malaria in Burkina Faso (PHASE2)
- Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Artesunate-amodiaquine fixed-dose combination CI brief — competitive landscape report
- Artesunate-amodiaquine fixed-dose combination updates RSS · CI watch RSS
- Epicentre portfolio CI
Frequently asked questions about Artesunate-amodiaquine fixed-dose combination
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Related
- Drug class: All Antimalarial combination drugs
- Target: All drugs targeting Plasmodium falciparum (multiple parasite targets)
- Manufacturer: Epicentre — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Uncomplicated malaria caused by Plasmodium falciparum
- Indication: Drugs for Malaria caused by Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae
- Also known as: AS-AQ Winthrop® Sanofi Aventis
- Compare: Artesunate-amodiaquine fixed-dose combination vs similar drugs
- Pricing: Artesunate-amodiaquine fixed-dose combination cost, discount & access