Anthelmintic

This page covers all Anthelmintic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Cytochrome P450 1A2, Calcium channels in parasitic flatworms, Nicotinic acetylcholine receptors (nematode-specific).

Targets

Cytochrome P450 1A2 · Calcium channels in parasitic flatworms · Nicotinic acetylcholine receptors (nematode-specific) · Arachidonate 5-lipoxygenase · Beta-tubulin

Marketed (5)

• Bovizole · Infectious Disease
• Biltricide® · Merck KGaA, Darmstadt, Germany · Infectious Disease / Parasitology
  Praziquantel causes muscular paralysis and death of parasitic worms by increasing cell membrane permeability to calcium ions.
• Oxantel Pamoate · Swiss Tropical & Public Health Institute · Infectious Diseases / Parasitology
  Oxantel pamoate is an anthelmintic that depolarizes and paralyzes nematode muscles, causing expulsion of hookworms and other intestinal roundworms.
• (+/-)-Oxamniquine · Infectious Disease
• Caricide · Pfizer · Infectious Disease

Phase 3 pipeline (2)

• similar placebo to mebendazole · Swiss Tropical & Public Health Institute · Infectious Diseases
  This drug works by inhibiting the action of a specific enzyme involved in the lifecycle of parasitic worms.
• ivermectin cream 0.5% · Rabin Medical Center · Dermatology
  Ivermectin cream 0.5% works by killing Demodex mites and other microfilariae that cause rosacea.