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Oxantel Pamoate
Oxantel pamoate is an anthelmintic that depolarizes and paralyzes nematode muscles, causing expulsion of hookworms and other intestinal roundworms.
Oxantel pamoate is an anthelmintic that depolarizes and paralyzes nematode muscles, causing expulsion of hookworms and other intestinal roundworms. Used for Hookworm infection (Necator americanus and Ancylostoma duodenale), Trichuris trichiura (whipworm) infection.
At a glance
| Generic name | Oxantel Pamoate |
|---|---|
| Sponsor | Swiss Tropical & Public Health Institute |
| Drug class | Anthelmintic |
| Target | Nicotinic acetylcholine receptors (nematode-specific) |
| Modality | Small molecule |
| Therapeutic area | Infectious Diseases / Parasitology |
| Phase | FDA-approved |
Mechanism of action
Oxantel pamoate acts as a nicotinic acetylcholine receptor agonist in parasitic nematodes, leading to sustained depolarization and spastic paralysis of the worm musculature. This immobilizes the parasites, allowing them to be expelled from the gastrointestinal tract. It is particularly effective against hookworms (Necator americanus and Ancylostoma duodenale) and Trichuris trichiura.
Approved indications
- Hookworm infection (Necator americanus and Ancylostoma duodenale)
- Trichuris trichiura (whipworm) infection
Common side effects
- Gastrointestinal disturbances (nausea, abdominal pain)
- Diarrhea
- Dizziness
Key clinical trials
- Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets (PHASE1)
- Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura (PHASE2)
- Triple Combinations Against Hookworm Infections in Lao (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Oxantel Pamoate CI brief — competitive landscape report
- Oxantel Pamoate updates RSS · CI watch RSS
- Swiss Tropical & Public Health Institute portfolio CI