{"id":"oxantel-pamoate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, abdominal pain)"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1240977","moleculeType":"Small molecule","molecularWeight":"216.28"},"_dailymed":{"setId":"a303d3b6-5083-4acd-ab43-4addeb1e270f","title":"OXANTEL PAMOATE POWDER [LETCO MEDICAL, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxantel pamoate acts as a nicotinic acetylcholine receptor agonist in parasitic nematodes, leading to sustained depolarization and spastic paralysis of the worm musculature. This immobilizes the parasites, allowing them to be expelled from the gastrointestinal tract. It is particularly effective against hookworms (Necator americanus and Ancylostoma duodenale) and Trichuris trichiura.","oneSentence":"Oxantel pamoate is an anthelmintic that depolarizes and paralyzes nematode muscles, causing expulsion of hookworms and other intestinal roundworms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:12.070Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hookworm infection (Necator americanus and Ancylostoma duodenale)"},{"name":"Trichuris trichiura (whipworm) infection"}]},"trialDetails":[{"nctId":"NCT06606860","phase":"PHASE1","title":"Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets","status":"COMPLETED","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2025-01-27","conditions":"Healthy","enrollment":45},{"nctId":"NCT06720259","phase":"PHASE2","title":"Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura","status":"COMPLETED","sponsor":"Jennifer Keiser","startDate":"2025-04-16","conditions":"Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection","enrollment":163},{"nctId":"NCT03278431","phase":"PHASE4","title":"Triple Combinations Against Hookworm Infections in Lao","status":"COMPLETED","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2017-09-27","conditions":"Hookworm Infection","enrollment":420}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":47,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oxantel Pamoate","genericName":"Oxantel Pamoate","companyName":"Swiss Tropical & Public Health Institute","companyId":"swiss-tropical-public-health-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxantel pamoate is an anthelmintic that depolarizes and paralyzes nematode muscles, causing expulsion of hookworms and other intestinal roundworms. Used for Hookworm infection (Necator americanus and Ancylostoma duodenale), Trichuris trichiura (whipworm) infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}