Who are topical vitamin B12's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Cyanocobalamin Co 57, Vitamin B12 (Cyanocobalamin), Methylcobalamin (methylB12), Vitamin B12, Methyl B12, Mecobalamin IM injection.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

topical vitamin B12 — Competitive Intelligence Brief

topical vitamin B12 (topical vitamin B12) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Area: Dermatology.

phase 3 Methionine synthase Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

topical vitamin B12 (topical vitamin B12) — Ruhr University of Bochum. Topical vitamin B12 is thought to act as a coenzyme for methionine synthase, facilitating the conversion of homocysteine to methionine.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
topical vitamin B12 TARGET	topical vitamin B12	Ruhr University of Bochum	phase 3		Methionine synthase
Cyanocobalamin Co 57	cyanocobalamin (57Co)	Mallinckrodt	marketed	Radioactive Diagnostic Agent	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial, Methionine synthase, Methionine synthase reductase	1968-01-01
Vitamin B12 (Cyanocobalamin)	Vitamin B12 (Cyanocobalamin)	University of Aarhus	marketed	Vitamin / Essential nutrient	Methionine synthase; methylmalonyl-CoA mutase
Methylcobalamin (methylB12)	Methylcobalamin (methylB12)	Arkansas Children's Hospital Research Institute	marketed	Vitamin B12 supplement / Cobalamin	Methionine synthase; methylmalonyl-CoA mutase cofactor
Vitamin B12	Vitamin B12	Acrotech Biopharma Inc.	marketed	Vitamin / Essential nutrient	Methionine synthase, methylmalonyl-CoA mutase
Methyl B12	Methyl B12	University of California, San Francisco	marketed	Vitamin B12 supplement	Methionine synthase
Mecobalamin IM injection	Mecobalamin IM injection	Eisai Co., Ltd.	marketed	Vitamin B12 analog	Methionine synthase; B12-dependent enzymes

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape

No sponsor landscape data.

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Cite this brief

Drug Landscape (2026). topical vitamin B12 — Competitive Intelligence Brief. https://druglandscape.com/ci/topical-vitamin-b12. Accessed 2026-05-16.

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