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Methyl B12
Methylcobalamin (Methyl B12) acts as a coenzyme in one-carbon transfer reactions and methionine synthesis, supporting DNA synthesis, myelin formation, and neurological function.
Methylcobalamin (Methyl B12) acts as a coenzyme in one-carbon transfer reactions and methionine synthesis, supporting DNA synthesis, myelin formation, and neurological function. Used for Vitamin B12 deficiency, Pernicious anemia, B12 deficiency-related neuropathy.
At a glance
| Generic name | Methyl B12 |
|---|---|
| Also known as | Vitamin B12, methylcobalamin |
| Sponsor | University of California, San Francisco |
| Drug class | Vitamin B12 supplement |
| Target | Methionine synthase |
| Modality | Small molecule |
| Therapeutic area | Hematology / Neurology |
| Phase | FDA-approved |
Mechanism of action
Methyl B12 is the active, methylated form of vitamin B12 that participates in the methionine synthase reaction, converting homocysteine to methionine. This is essential for DNA synthesis, red blood cell formation, and maintenance of myelin sheaths around nerves. It is used therapeutically to correct B12 deficiency and support neurological and hematological function.
Approved indications
- Vitamin B12 deficiency
- Pernicious anemia
- Neurological complications of B12 deficiency
- Methylmalonic acidemia and homocystinuria
Common side effects
- Injection site reactions
- Headache
- Dizziness
- Allergic reactions (rare)
Key clinical trials
- Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients (NA)
- Methyl-donor Nutrient Supplementation and Methylation Profile in Lupus Patients With Obesity (NA)
- Prenatal Iodine Supplementation and Early Childhood Neurodevelopment (PHASE4)
- Combination Therapy of Different Antidepressants With Dietary Supplements (NA)
- Study of the Effect of 12-week Dietary Supplementation With a Multicomponent Nutritional Supplement on Nails and Skin (NA)
- Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism (PHASE2, PHASE3)
- Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People (NA)
- Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methyl B12 CI brief — competitive landscape report
- Methyl B12 updates RSS · CI watch RSS
- University of California, San Francisco portfolio CI