{"id":"methyl-b12","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":{"setId":"7106bc67-1971-4cc5-a60c-9a089a4721fa","title":"ORAL HCG ACTIVATOR (HYPOTHALAMUS, HEPAR SUIS, METHYL B12, RENAL SUIS, GAMBOGIA, GRAPHITES) SOLUTION/ DROPS [ABCO LABORATORIES, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methyl B12 is the active, methylated form of vitamin B12 that participates in the methionine synthase reaction, converting homocysteine to methionine. This is essential for DNA synthesis, red blood cell formation, and maintenance of myelin sheaths around nerves. It is used therapeutically to correct B12 deficiency and support neurological and hematological function.","oneSentence":"Methylcobalamin (Methyl B12) acts as a coenzyme in one-carbon transfer reactions and methionine synthesis, supporting DNA synthesis, myelin formation, and neurological function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:00:57.106Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin B12 deficiency"},{"name":"Pernicious anemia"},{"name":"Neurological complications of B12 deficiency"},{"name":"Methylmalonic acidemia and homocystinuria"}]},"trialDetails":[{"nctId":"NCT06885827","phase":"NA","title":"Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients","status":"RECRUITING","sponsor":"Karolinska Institutet","startDate":"2025-03-31","conditions":"Open-angle Glaucoma, Pseudoexfoliation Glaucoma","enrollment":80},{"nctId":"NCT05097365","phase":"NA","title":"Methyl-donor Nutrient Supplementation and Methylation Profile in Lupus Patients With Obesity","status":"ENROLLING_BY_INVITATION","sponsor":"University of Sao Paulo","startDate":"2022-01-01","conditions":"Overweight and Obesity, Lupus Erythematosus","enrollment":51},{"nctId":"NCT04586348","phase":"PHASE4","title":"Prenatal Iodine Supplementation and Early Childhood Neurodevelopment","status":"ACTIVE_NOT_RECRUITING","sponsor":"South Australian Health and Medical Research Institute","startDate":"2021-01-18","conditions":"Pregnancy Related, Neurodevelopmental Disorders, Nutrition Disorder, Fetal","enrollment":794},{"nctId":"NCT05931965","phase":"NA","title":"Combination Therapy of Different Antidepressants With Dietary Supplements","status":"COMPLETED","sponsor":"Riphah International University","startDate":"2022-10-05","conditions":"Depression","enrollment":88},{"nctId":"NCT05100680","phase":"NA","title":"Study of the Effect of 12-week Dietary Supplementation With a Multicomponent Nutritional Supplement on Nails and Skin","status":"COMPLETED","sponsor":"VIST - Faculty of Applied Sciences","startDate":"2019-11-25","conditions":"Nail Damage","enrollment":34},{"nctId":"NCT00273650","phase":"PHASE2, PHASE3","title":"Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2005-07","conditions":"Autistic Disorder","enrollment":30},{"nctId":"NCT02837367","phase":"NA","title":"Use of Nutrigenomic Models for the Personalized Treatment With Medical Foods in Obese People","status":"UNKNOWN","sponsor":"University of Medicine and Pharmacy \"Victor Babes\" Timisoara","startDate":"2016-09","conditions":"Obesity, Dyslipidemia","enrollment":600},{"nctId":"NCT01381354","phase":"PHASE1","title":"Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)","status":"COMPLETED","sponsor":"University of Iowa","startDate":"2010-10","conditions":"Multiple Sclerosis","enrollment":38},{"nctId":"NCT01095211","phase":"NA","title":"B-vitamins Treatment for Improvement of Cognitive Function","status":"COMPLETED","sponsor":"Universität des Saarlandes","startDate":"2003-01","conditions":"Cognitive Function, Metabolic Improvements","enrollment":79},{"nctId":"NCT01864824","phase":"PHASE1","title":"Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial","status":"COMPLETED","sponsor":"Harvard School of Public Health (HSPH)","startDate":"2013-06","conditions":"Heart Rate, Heart Rate Variability, Inflammation","enrollment":10},{"nctId":"NCT01039792","phase":"PHASE2, PHASE3","title":"Trial of Methyl B12 on Behavioral and Metabolic Measures in Children With Autism","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2010-01","conditions":"Autistic Disorder","enrollment":57},{"nctId":"NCT02696512","phase":"PHASE1, PHASE2","title":"A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness","status":"UNKNOWN","sponsor":"International Brain Research Foundation","startDate":"2016-03","conditions":"Brain Injury","enrollment":30},{"nctId":"NCT00692315","phase":"NA","title":"Treating Oxidative Stress in Children With Autism","status":"COMPLETED","sponsor":"Arkansas Children's Hospital Research Institute","startDate":"2006-09","conditions":"Autistic Disorder","enrollment":40},{"nctId":"NCT00717730","phase":"PHASE2","title":"Folic Acid and Vitamin B12 in Young Indian Children","status":"COMPLETED","sponsor":"Tor A. Strand","startDate":"2010-01","conditions":"Diarrhea, Pneumonia","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[{"count":10,"reaction":"HEADACHE"},{"count":8,"reaction":"INSOMNIA"},{"count":6,"reaction":"ARTHRALGIA"},{"count":6,"reaction":"DIZZINESS"},{"count":6,"reaction":"VOMITING"},{"count":5,"reaction":"DRUG INEFFECTIVE"},{"count":5,"reaction":"FATIGUE"},{"count":5,"reaction":"NAUSEA"},{"count":4,"reaction":"ASTHENIA"},{"count":4,"reaction":"FALL"}],"_approvalHistory":[],"publicationCount":42,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vitamin B12","methylcobalamin"],"phase":"marketed","status":"active","brandName":"Methyl B12","genericName":"Methyl B12","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylcobalamin (Methyl B12) acts as a coenzyme in one-carbon transfer reactions and methionine synthesis, supporting DNA synthesis, myelin formation, and neurological function. Used for Vitamin B12 deficiency, Pernicious anemia, B12 deficiency-related neuropathy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}