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Vitamin B12 (Cyanocobalamin)
Vitamin B12 (cyanocobalamin) acts as a coenzyme essential for DNA synthesis, myelin formation, and cellular metabolism.
Vitamin B12 (cyanocobalamin) acts as a coenzyme essential for DNA synthesis, myelin formation, and cellular metabolism. Used for Vitamin B12 deficiency anemia, Pernicious anemia, B12 deficiency due to malabsorption or dietary insufficiency.
At a glance
| Generic name | Vitamin B12 (Cyanocobalamin) |
|---|---|
| Also known as | B12 Ankermann® |
| Sponsor | University of Aarhus |
| Drug class | Vitamin / Essential nutrient |
| Target | Methionine synthase; methylmalonyl-CoA mutase |
| Modality | Small molecule |
| Therapeutic area | Hematology; Neurology; Nutritional deficiency |
| Phase | FDA-approved |
Mechanism of action
Cyanocobalamin is converted to its active forms (methylcobalamin and adenosylcobalamin) in the body, where it serves as a critical cofactor for methionine synthase and methylmalonyl-CoA mutase enzymes. These enzymes are required for proper DNA replication, red blood cell formation, and nervous system function. B12 deficiency leads to megaloblastic anemia and neurological complications that are reversed by supplementation.
Approved indications
- Vitamin B12 deficiency anemia
- Pernicious anemia
- B12 deficiency due to malabsorption or dietary insufficiency
- Neurological complications of B12 deficiency (peripheral neuropathy, subacute combined degeneration)
Common side effects
- Injection site reactions (pain, erythema)
- Hypokalemia
- Headache
- Dizziness
- Allergic reactions (rare)
Key clinical trials
- Iron and Immune Response to Vaccine (IRONMUM) (NA)
- Clinical and Laboratory Study of Methylmalonic Acidemia
- Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older
- Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment (NA)
- Vegan Diet and Immune-Inflammatory Outcomes in Asthma and Healthy Adults (NA)
- Microbiome and Health Indicators in People With Obesity, Prediabetes and Type 2 Diabetes Undergoing a Lifestyle Intervention (NA)
- Combination Gerotherapeutic Interventions for Healthspan Improvement (PHASE3)
- A Study on Hydroxocobalamin Given to Healthy Individual to Monitor Symptoms (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vitamin B12 (Cyanocobalamin) CI brief — competitive landscape report
- Vitamin B12 (Cyanocobalamin) updates RSS · CI watch RSS
- University of Aarhus portfolio CI