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Methylcobalamin (methylB12)
Methylcobalamin is an active form of vitamin B12 that serves as a cofactor for methionine synthase and other enzymes involved in DNA synthesis, myelin formation, and neurological function.
Methylcobalamin is an active form of vitamin B12 that serves as a cofactor for methionine synthase and other enzymes involved in DNA synthesis, myelin formation, and neurological function. Used for Vitamin B12 deficiency, Pernicious anemia, Neurological complications of B12 deficiency.
At a glance
| Generic name | Methylcobalamin (methylB12) |
|---|---|
| Also known as | Vitamin B12 |
| Sponsor | Arkansas Children's Hospital Research Institute |
| Drug class | Vitamin B12 supplement / Cobalamin |
| Target | Methionine synthase; methylmalonyl-CoA mutase cofactor |
| Modality | Small molecule |
| Therapeutic area | Neurology; Hematology; Nutritional deficiency |
| Phase | FDA-approved |
Mechanism of action
Methylcobalamin is a coenzyme form of vitamin B12 that participates in one-carbon metabolism and the conversion of homocysteine to methionine. It is essential for proper DNA synthesis, red blood cell formation, and maintenance of myelin sheaths around nerves. Unlike cyanocobalamin, methylcobalamin is directly available for cellular use without requiring metabolic conversion.
Approved indications
- Vitamin B12 deficiency
- Pernicious anemia
- Neurological complications of B12 deficiency
- Methylmalonic aciduria (in some cases)
Common side effects
- Injection site reactions
- Headache
- Dizziness
- Allergic reactions (rare)
Key clinical trials
- Hand and Foot Bath for Taxane-Induced Peripheral Neurotoxicity (PHASE4)
- Treating Oxidative Stress in Children With Autism (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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