{"id":"methylcobalamin-methylb12","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":{"chemblId":"CHEMBL4297672","moleculeType":"Small molecule","molecularWeight":"1344.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylcobalamin is a coenzyme form of vitamin B12 that participates in one-carbon metabolism and the conversion of homocysteine to methionine. It is essential for proper DNA synthesis, red blood cell formation, and maintenance of myelin sheaths around nerves. Unlike cyanocobalamin, methylcobalamin is directly available for cellular use without requiring metabolic conversion.","oneSentence":"Methylcobalamin is an active form of vitamin B12 that serves as a cofactor for methionine synthase and other enzymes involved in DNA synthesis, myelin formation, and neurological function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:44.102Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin B12 deficiency"},{"name":"Pernicious anemia"},{"name":"Neurological complications of B12 deficiency"},{"name":"Methylmalonic aciduria (in some cases)"}]},"trialDetails":[{"nctId":"NCT07344974","phase":"PHASE4","title":"Hand and Foot Bath for Taxane-Induced Peripheral Neurotoxicity","status":"NOT_YET_RECRUITING","sponsor":"Peking University Cancer Hospital & Institute","startDate":"2026-02-01","conditions":"Breast Cancer","enrollment":78},{"nctId":"NCT00692315","phase":"NA","title":"Treating Oxidative Stress in Children With Autism","status":"COMPLETED","sponsor":"Arkansas Children's Hospital Research Institute","startDate":"2006-09","conditions":"Autistic Disorder","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vitamin B12"],"phase":"marketed","status":"active","brandName":"Methylcobalamin (methylB12)","genericName":"Methylcobalamin (methylB12)","companyName":"Arkansas Children's Hospital Research Institute","companyId":"arkansas-children-s-hospital-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylcobalamin is an active form of vitamin B12 that serves as a cofactor for methionine synthase and other enzymes involved in DNA synthesis, myelin formation, and neurological function. Used for Vitamin B12 deficiency, Pernicious anemia, Neurological complications of B12 deficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}