Sevoflurane intravenous anesthesia — Competitive Intelligence Brief

Sevoflurane intravenous anesthesia (Sevoflurane intravenous anesthesia) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Volatile anesthetic. Area: Anesthesiology.

phase 3 Volatile anesthetic GABA_A receptor Anesthesiology Small molecule

Target snapshot

Sevoflurane intravenous anesthesia (Sevoflurane intravenous anesthesia) — The Cleveland Clinic. Sevoflurane acts as a general anesthetic by modulating the activity of the GABA_A receptor, leading to a decrease in neuronal excitability.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Sevoflurane intravenous anesthesia TARGET	Sevoflurane intravenous anesthesia	The Cleveland Clinic	phase 3	Volatile anesthetic	GABA_A receptor
The midazolam ketamine group	The midazolam ketamine group	Kasr El Aini Hospital	phase 3	Benzodiazepine and NMDA receptor antagonist	GABA_A receptor, NMDA receptor
Remifentanil and/or propofol	Remifentanil and/or propofol	Alder Hey Children's NHS Foundation Trust	phase 3	Opioid analgesic, Sedative-hypnotic	Opioid receptors, GABA_A receptor
Propofol-Lipuro	Propofol-Lipuro	University Hospital, Grenoble	phase 3	GABA receptor agonist	GABA_A receptor
propofol (drug)	propofol (drug)	B. Braun Melsungen AG	phase 3	GABA receptor agonist	GABA_A receptor
Stiripentol Oral Capsule	Stiripentol Oral Capsule	Biocodex	phase 3	GABA_A receptor modulator	GABA_A receptor
topiramate, propranolol	topiramate, propranolol	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	phase 3	Anticonvulsant	Voltage-dependent sodium channels, GABA_A receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Volatile anesthetic class)

1. Medical University of Gdansk · 2 drugs in this class
2. Assistance Publique - Hôpitaux de Paris · 1 drug in this class
3. Federal University of São Paulo · 1 drug in this class
4. King's College Hospital NHS Trust · 1 drug in this class
5. London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · 1 drug in this class
6. The Cleveland Clinic · 1 drug in this class
7. University Hospital, Basel, Switzerland · 1 drug in this class
8. Asan Medical Center · 1 drug in this class
9. University Hospital, Clermont-Ferrand · 1 drug in this class