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Sevoflurane intravenous anesthesia
Sevoflurane acts as a general anesthetic by modulating the activity of the GABA_A receptor, leading to a decrease in neuronal excitability.
Sevoflurane acts as a general anesthetic by modulating the activity of the GABA_A receptor, leading to a decrease in neuronal excitability. Used for General anesthesia for surgical procedures.
At a glance
| Generic name | Sevoflurane intravenous anesthesia |
|---|---|
| Also known as | Sevoflurane |
| Sponsor | The Cleveland Clinic |
| Drug class | Volatile anesthetic |
| Target | GABA_A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Sevoflurane is a volatile anesthetic agent that exerts its effects by enhancing the activity of the inhibitory neurotransmitter GABA at the GABA_A receptor. This results in a decrease in neuronal excitability, leading to a loss of consciousness and analgesia. The exact mechanism of action is not fully understood, but it is thought to involve the modulation of GABA_A receptor subunits and the inhibition of excitatory neurotransmitter release.
Approved indications
- General anesthesia for surgical procedures
Common side effects
- Nausea and vomiting
- Respiratory depression
- Cardiovascular effects (e.g. hypotension)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients (NA)
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Anesthesia sTrategy foR Organ Procurement In braiN dEath (PHASE3)
- General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients (NA)
- Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane intravenous anesthesia CI brief — competitive landscape report
- Sevoflurane intravenous anesthesia updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI