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Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium (SUPRA)
Heart surgery is a considerable source of stress for the myocardium that must be minimized. Troponin Ic is a reliable marker to determine the level of this myocardial stress. Studies have shown that post-conditioning with AVH has a protective effect on the myocardium, if the treatment is initiated at the start of the ischemia. The aim of this study is to evaluate the protective effect on the myocardium (by measuring troponin levels) of the association of pre-conditioning and post-conditioning with Sevoflurane (AVH) sedation administered during and after scheduled surgery for valve replacement, via sternotomy or thoracotomy compared with total intravenous anaesthesia with Propofol.
Details
| Lead sponsor | Centre Hospitalier Universitaire Dijon |
|---|---|
| Phase | PHASE4 |
| Status | COMPLETED |
| Enrolment | 82 |
| Start date | Wed Oct 14 2015 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Sep 04 2017 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Cardiac Surgery
Interventions
- total anaesthesia and postoperative inhaled sedation with Sevoflurane
- total intravenous anaesthesia with Propofol.
Countries
France