Who are Pyrimethamine/sulfadoxine's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): IPTp-SP, sulfadoxine-pyrimethamine and chlorproguanil-dapsone, Sulfadoxine-pyrimethamine used for IPTi, Intermittent preventive treatment:sulphadoxine-pyrimethamine, sulfadoxine pyrimethamine plus piperaquine, IPTp-sulphadoxine-pyrimethamine.

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Last reviewed 2026-05-17 · How we verify

Pyrimethamine/sulfadoxine — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pyrimethamine/sulfadoxine (Pyrimethamine/sulfadoxine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antifolate antimalarial combination. Area: Infectious Disease.

phase 3 Antifolate antimalarial combination Dihydrofolate reductase (pyrimethamine); dihydropteroate synthase (sulfadoxine) Infectious Disease Small molecule Live · refreshed every 30 min

Target snapshot

Pyrimethamine/sulfadoxine (Pyrimethamine/sulfadoxine) — London School of Hygiene and Tropical Medicine. Pyrimethamine and sulfadoxine work together to inhibit folate metabolism in malaria parasites, blocking nucleotide synthesis and parasite replication.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Pyrimethamine/sulfadoxine TARGET	Pyrimethamine/sulfadoxine	London School of Hygiene and Tropical Medicine	phase 3	Antifolate antimalarial combination	Dihydrofolate reductase (pyrimethamine); dihydropteroate synthase (sulfadoxine)
IPTp-SP	IPTp-SP	Kenya Medical Research Institute	marketed	Antifolate antimalarial combination	Dihydrofolate reductase (DHFR)
sulfadoxine-pyrimethamine and chlorproguanil-dapsone	sulfadoxine-pyrimethamine and chlorproguanil-dapsone	London School of Hygiene and Tropical Medicine	phase 3	Antifolate antimalarial combination	Dihydrofolate reductase; dihydropteroate synthase
Sulfadoxine-pyrimethamine used for IPTi	Sulfadoxine-pyrimethamine used for IPTi	Swiss Tropical & Public Health Institute	phase 3	Antifolate antimalarial combination	Dihydropteroate synthase; Dihydrofolate reductase
Intermittent preventive treatment:sulphadoxine-pyrimethamine	Intermittent preventive treatment:sulphadoxine-pyrimethamine	London School of Hygiene and Tropical Medicine	phase 3	Antifolate antimalarial combination	Dihydropteroate synthase and dihydrofolate reductase
sulfadoxine pyrimethamine plus piperaquine	sulfadoxine pyrimethamine plus piperaquine	London School of Hygiene and Tropical Medicine	phase 3	Antifolate antimalarial combination with quinoline antimalarial	Plasmodium dihydrofolate reductase, dihydropteroate synthase, and parasite mitochondria
IPTp-sulphadoxine-pyrimethamine	IPTp-sulphadoxine-pyrimethamine	London School of Hygiene and Tropical Medicine	phase 3	Antifolate antimalarial combination	Dihydrofolate reductase; Dihydropteroate synthase

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antifolate antimalarial combination class)

London School of Hygiene and Tropical Medicine · 4 drugs in this class
Kenya Medical Research Institute · 1 drug in this class
Swiss Tropical & Public Health Institute · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Pyrimethamine/sulfadoxine — Competitive Intelligence Brief. https://druglandscape.com/ci/pyrimethamine-sulfadoxine. Accessed 2026-05-17.

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