Who are Nuedexta (20/10)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): QUINIDINE, placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan, diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan, AXS-05, Dextromethorphan Oral Solution, Dextromethorphan hydrobromide with guaifenesin.

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Last reviewed 2026-05-15 · How we verify

Nuedexta (20/10) — Competitive Intelligence Brief

Nuedexta (20/10) (Nuedexta (20/10)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Sigma-1 receptor agonist combination. Area: Neurology.

marketed Sigma-1 receptor agonist combination Sigma-1 receptor Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Nuedexta (20/10) (Nuedexta (20/10)) — St. Joseph's Hospital and Medical Center, Phoenix. Nuedexta combines dextromethorphan (a sigma-1 receptor agonist) and quinidine (a CYP2D6 inhibitor) to reduce involuntary emotional expression disorder (pseudobulbar affect) by modulating emotional pathways in the brain.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Nuedexta (20/10) TARGET	Nuedexta (20/10)	St. Joseph's Hospital and Medical Center, Phoenix	marketed	Sigma-1 receptor agonist combination	Sigma-1 receptor
QUINIDINE	QUINIDINE		marketed		sigma-1 receptor, NMDA receptor, CYP2D6	1950-01-01
placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan	placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan	Montefiore Medical Center	marketed	Combination cold and cough remedy	H1 receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); sigma-1 receptor and NMDA receptor (dextromethorphan)
diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	Montefiore Medical Center	marketed	Combination cold/cough/allergy remedy	H1 histamine receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); NMDA receptor and sigma-1 receptor (dextromethorphan)
AXS-05	AXS-05	Axsome Therapeutics, Inc.	marketed	Combination antidepressant (NMDA antagonist + norepinephrine-dopamine reuptake inhibitor)	Sigma-1 receptor, NMDA receptor, norepinephrine transporter, dopamine transporter
Dextromethorphan Oral Solution	Dextromethorphan Oral Solution	Helsinki University Central Hospital	marketed	Non-opioid antitussive	NMDA receptor antagonist; sigma-1 receptor
Dextromethorphan hydrobromide with guaifenesin	Dextromethorphan hydrobromide with guaifenesin	Washington University School of Medicine	marketed	Antitussive/expectorant combination	Sigma-1 receptor, NMDA receptor (dextromethorphan); non-specific expectorant mechanism (guaifenesin)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Sigma-1 receptor agonist combination class)

St. Joseph's Hospital and Medical Center, Phoenix · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Nuedexta (20/10) — Competitive Intelligence Brief. https://druglandscape.com/ci/nuedexta-20-10. Accessed 2026-05-15.

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