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Dextromethorphan hydrobromide with guaifenesin
Dextromethorphan hydrobromide with guaifenesin is a Antitussive/expectorant combination Small molecule drug developed by Washington University School of Medicine. It is currently FDA-approved for Cough and mucus congestion associated with cold, flu, or upper respiratory infection. Also known as: Robitussin.
Dextromethorphan suppresses cough by acting as a non-opioid antitussive agent in the central nervous system, while guaifenesin thins mucus to facilitate clearance.
Dextromethorphan suppresses cough by acting as a non-opioid antitussive agent in the central nervous system, while guaifenesin thins mucus to facilitate clearance. Used for Cough and mucus congestion associated with cold, flu, or upper respiratory infection.
At a glance
| Generic name | Dextromethorphan hydrobromide with guaifenesin |
|---|---|
| Also known as | Robitussin |
| Sponsor | Washington University School of Medicine |
| Drug class | Antitussive/expectorant combination |
| Target | Sigma-1 receptor, NMDA receptor (dextromethorphan); non-specific expectorant mechanism (guaifenesin) |
| Modality | Small molecule |
| Therapeutic area | Respiratory/Cough |
| Phase | FDA-approved |
Mechanism of action
Dextromethorphan is a sigma-1 receptor agonist and NMDA receptor antagonist that depresses the cough center in the medulla oblongata, reducing the urge to cough. Guaifenesin is an expectorant that increases respiratory tract fluid secretion, reducing mucus viscosity and making it easier to expectorate. Together, they provide complementary cough suppression and mucus clearance.
Approved indications
- Cough and mucus congestion associated with cold, flu, or upper respiratory infection
Common side effects
- Drowsiness
- Dizziness
- Nausea
- Headache
Key clinical trials
- A Clinical Evidence Study Evaluating Quality of Life Parameters Following Treatment With Robitussin (PHASE4)
- PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates (PHASE1)
- Effectiveness of Antitussives, Anticholinergics and Honey Versus Usual Care in Adults With Acute Bronchitis. (PHASE4)
- Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo (PHASE4)
- Efficacy Study of Dextromethorphan to Treat Rheumatoid Arthritis (NA)
- Treatment of Acute Sinusitis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dextromethorphan hydrobromide with guaifenesin CI brief — competitive landscape report
- Dextromethorphan hydrobromide with guaifenesin updates RSS · CI watch RSS
- Washington University School of Medicine portfolio CI
Frequently asked questions about Dextromethorphan hydrobromide with guaifenesin
What is Dextromethorphan hydrobromide with guaifenesin?
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Is Dextromethorphan hydrobromide with guaifenesin also known as anything else?
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Related
- Drug class: All Antitussive/expectorant combination drugs
- Target: All drugs targeting Sigma-1 receptor, NMDA receptor (dextromethorphan); non-specific expectorant mechanism (guaifenesin)
- Manufacturer: Washington University School of Medicine — full pipeline
- Therapeutic area: All drugs in Respiratory/Cough
- Indication: Drugs for Cough and mucus congestion associated with cold, flu, or upper respiratory infection
- Also known as: Robitussin
- Compare: Dextromethorphan hydrobromide with guaifenesin vs similar drugs
- Pricing: Dextromethorphan hydrobromide with guaifenesin cost, discount & access