Last reviewed · How we verify
placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan
This combination product uses an antihistamine, decongestant, and cough suppressant to reduce cold and cough symptoms through multiple pathways.
This combination product uses an antihistamine, decongestant, and cough suppressant to reduce cold and cough symptoms through multiple pathways. Used for Common cold symptoms including cough, nasal congestion, and sneezing, Cough suppression associated with upper respiratory infections.
At a glance
| Generic name | placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan |
|---|---|
| Sponsor | Montefiore Medical Center |
| Drug class | Combination cold and cough remedy |
| Target | H1 receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); sigma-1 receptor and NMDA receptor (dextromethorphan) |
| Modality | Small molecule |
| Therapeutic area | Respiratory/Cold and Cough |
| Phase | FDA-approved |
Mechanism of action
Diphenhydramine is a first-generation antihistamine that blocks H1 receptors to reduce histamine-mediated symptoms like itching and sneezing. Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction to relieve nasal congestion. Dextromethorphan is a non-opioid cough suppressant that acts on the cough center in the medulla. The placebo component serves as a control.
Approved indications
- Common cold symptoms including cough, nasal congestion, and sneezing
- Cough suppression associated with upper respiratory infections
Common side effects
- Drowsiness
- Dizziness
- Dry mouth
- Nervousness or excitability
- Nausea
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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