{"id":"placebo-diphenhydramine-phenylephrine-cocoa-dextromethorphan","safety":{"commonSideEffects":[{"rate":"10-25","effect":"Drowsiness"},{"rate":"5-15","effect":"Dizziness"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Nervousness or excitability"},{"rate":"2-5","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL52440","moleculeType":"Small molecule","molecularWeight":"271.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diphenhydramine is a first-generation antihistamine that blocks H1 receptors to reduce histamine-mediated symptoms like itching and sneezing. Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction to relieve nasal congestion. Dextromethorphan is a non-opioid cough suppressant that acts on the cough center in the medulla. The placebo component serves as a control.","oneSentence":"This combination product uses an antihistamine, decongestant, and cough suppressant to reduce cold and cough symptoms through multiple pathways.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:00:39.376Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Common cold symptoms including cough, nasal congestion, and sneezing"},{"name":"Cough suppression associated with upper respiratory infections"}]},"trialDetails":[{"nctId":"NCT02062710","phase":"PHASE4","title":"Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2014-01","conditions":"Cough Reflex Sensitivity","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan","genericName":"placebo; diphenhydramine/phenylephrine/cocoa; dextromethorphan","companyName":"Montefiore Medical Center","companyId":"montefiore-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product uses an antihistamine, decongestant, and cough suppressant to reduce cold and cough symptoms through multiple pathways. Used for Common cold symptoms including cough, nasal congestion, and sneezing, Cough suppression associated with upper respiratory infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}