Who are Natto extract (Nattokinase)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Tnkase, Fibrinolytic once daily, reteplase 10+10 U, TNKase, TachoSil, Tenecteplase or Alteplase.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Natto extract (Nattokinase) — Competitive Intelligence Brief

Natto extract (Nattokinase) (Natto extract (Nattokinase)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Fibrinolytic enzyme. Area: Cardiovascular.

marketed Fibrinolytic enzyme Fibrin Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Natto extract (Nattokinase) (Natto extract (Nattokinase)) — Changhua Christian Hospital. Nattokinase is a serine protease enzyme that directly degrades fibrin clots and enhances fibrinolysis to promote thrombus dissolution.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Natto extract (Nattokinase) TARGET	Natto extract (Nattokinase)	Changhua Christian Hospital	marketed	Fibrinolytic enzyme	Fibrin
Tnkase	TENECTEPLASE	Roche	marketed		fibrin	2000-01-01
Fibrinolytic once daily	Fibrinolytic once daily	University of North Carolina, Chapel Hill	marketed	Fibrinolytic agent / Thrombolytic	Plasminogen / Fibrin
reteplase 10+10 U	reteplase 10+10 U	Sahlgrenska University Hospital	marketed	Fibrinolytic agent; tissue plasminogen activator (tPA) analog	Fibrin; plasminogen
TNKase	TNKase	Cedars-Sinai Medical Center	marketed	Fibrinolytic agent; tissue plasminogen activator (tPA)	Fibrin; plasminogen
TachoSil	TachoSil	GATT Technologies BV	marketed	Hemostatic agent / Fibrin sealant	Fibrinogen (conversion to fibrin via thrombin)
Tenecteplase or Alteplase	Tenecteplase or Alteplase	Insel Gruppe AG, University Hospital Bern	marketed	Tissue plasminogen activator (tPA); fibrinolytic agent	Plasminogen; fibrin

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Fibrinolytic enzyme class)

Changhua Christian Hospital · 1 drug in this class
Universitas Sebelas Maret · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Natto extract (Nattokinase) — Competitive Intelligence Brief. https://druglandscape.com/ci/natto-extract-nattokinase. Accessed 2026-05-16.

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