Last reviewed · How we verify
TachoSil
TachoSil is a hemostatic agent that combines fibrin glue with collagen to promote rapid blood clotting and wound sealing.
TachoSil is a hemostatic agent that combines fibrin glue with collagen to promote rapid blood clotting and wound sealing. Used for Hemostasis support in cardiovascular surgery, Hemostasis support in general surgery, Hemostasis support in orthopedic surgery.
At a glance
| Generic name | TachoSil |
|---|---|
| Also known as | Tachosil®, TachoSil is a sponge sealant patch that is coated with the active substances human fibrinogen and human thrombin., NCT01192022, fibrin sealant matrix, EU/1/04/277/001 |
| Sponsor | GATT Technologies BV |
| Drug class | Hemostatic agent / Fibrin sealant |
| Target | Fibrinogen (conversion to fibrin via thrombin) |
| Modality | Small molecule |
| Therapeutic area | Surgery / Hemostasis |
| Phase | FDA-approved |
Mechanism of action
TachoSil consists of a collagen patch coated with human fibrinogen and thrombin. When applied to a bleeding surface, the thrombin activates fibrinogen to form fibrin clots, while the collagen provides structural support. This combination creates a stable hemostatic seal that promotes tissue adhesion and accelerates hemostasis.
Approved indications
- Hemostasis support in cardiovascular surgery
- Hemostasis support in general surgery
- Hemostasis support in orthopedic surgery
Common side effects
- Allergic reaction
- Infection at application site
- Thromboembolism
Key clinical trials
- GATT-Patch Versus TachoSil in Liver Surgery (NA)
- Collagen Matrix in Oral Cancer Surgery
- NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery (NA)
- A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery (PHASE3)
- A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery (PHASE1, PHASE2)
- Trans Canal Tympanoplasty With Local Anesthesia Using Fat Graft and "TachoSil" (NA)
- Use of Fibrin Sealant Patch for Vein Anastomosis During Deceased Donor Liver Transplantation- Randomized Clinical Trial (PHASE4)
- Assessment of Long-term Effects of Tachosil
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- TachoSil CI brief — competitive landscape report
- TachoSil updates RSS · CI watch RSS
- GATT Technologies BV portfolio CI