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Luteal support with estrogen + progesterone — Competitive Intelligence Brief
marketed
Hormone replacement therapy
Progesterone receptor (PR) and estrogen receptor (ER)
Reproductive Medicine / Fertility
Small molecule
Live · refreshed every 30 min
Target snapshot
Luteal support with estrogen + progesterone (Luteal support with estrogen + progesterone) — Rabin Medical Center. Estrogen and progesterone supplementation during the luteal phase supports endometrial development and maintains pregnancy viability in assisted reproductive cycles.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Luteal support with estrogen + progesterone TARGET | Luteal support with estrogen + progesterone | Rabin Medical Center | marketed | Hormone replacement therapy | Progesterone receptor (PR) and estrogen receptor (ER) | |
| Estradiol + Progesterone | Estradiol + Progesterone | Productos Científicos S. A. de C. V. | marketed | Hormone replacement therapy / Oral contraceptive | Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ), Progesterone receptor (PR) | |
| Human chorionic gonadotrophin | Human chorionic gonadotrophin | The University of Hong Kong | marketed | Gonadotropin; Hormone replacement therapy | Luteinizing hormone receptor (LHCG receptor) | |
| Conjugated equine estrogen topical cream | Conjugated equine estrogen topical cream | University of Louisville | marketed | Topical hormone replacement therapy; estrogen | Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) | |
| Change in daily dosage of Growth Hormone | Change in daily dosage of Growth Hormone | Amsterdam UMC, location VUmc | marketed | Growth hormone replacement therapy | Growth hormone receptor (GHR) | |
| Estradiol/norethindrone acetate | Estradiol/norethindrone acetate | Myovant Sciences GmbH | marketed | Hormone replacement therapy (HRT) | Estrogen receptor alpha and beta; progesterone receptor | |
| Gabapentin, Estrogen and placebo administration | Gabapentin, Estrogen and placebo administration | University of Rochester | marketed | Combination therapy (gabapentinoid + hormone replacement therapy) | Voltage-gated calcium channel (alpha-2-delta subunit) for gabapentin; estrogen receptor for estrogen |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Hormone replacement therapy class)
- Rabin Medical Center · 2 drugs in this class
- Faculdade de Medicina do ABC · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Luteal support with estrogen + progesterone — Competitive Intelligence Brief. https://druglandscape.com/ci/luteal-support-with-estrogen-progesterone. Accessed 2026-05-17.
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