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Estradiol + Progesterone
Estradiol + Progesterone is a Hormone replacement therapy / Oral contraceptive Small molecule drug developed by Productos Científicos S. A. de C. V.. It is currently FDA-approved for Menopausal symptom relief (hot flashes, night sweats, vaginal dryness), Contraception, Hormone replacement therapy in postmenopausal women.
Estradiol and progesterone work together to replace or supplement endogenous sex hormones, regulating the menstrual cycle and supporting reproductive and metabolic functions.
Estradiol and progesterone work together to replace or supplement endogenous sex hormones, regulating the menstrual cycle and supporting reproductive and metabolic functions. Used for Menopausal symptom relief (hot flashes, night sweats, vaginal dryness), Contraception, Hormone replacement therapy in postmenopausal women.
At a glance
| Generic name | Estradiol + Progesterone |
|---|---|
| Sponsor | Productos Científicos S. A. de C. V. |
| Drug class | Hormone replacement therapy / Oral contraceptive |
| Target | Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ), Progesterone receptor (PR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Gynecology |
| Phase | FDA-approved |
Mechanism of action
Estradiol is a potent estrogen that binds to estrogen receptors (ERα and ERβ) throughout the body, while progesterone binds to progesterone receptors, together modulating the hypothalamic-pituitary-gonadal axis and target tissues. This combination is used in hormone replacement therapy (HRT) to alleviate menopausal symptoms and in oral contraceptives to prevent ovulation and regulate the menstrual cycle. The two hormones work synergistically to maintain endometrial stability, bone health, and cardiovascular function.
Approved indications
- Menopausal symptom relief (hot flashes, night sweats, vaginal dryness)
- Contraception
- Hormone replacement therapy in postmenopausal women
Common side effects
- Nausea
- Headache
- Breast tenderness
- Vaginal bleeding/spotting
- Thromboembolism (VTE/PE)
- Hypertension
- Weight gain
Key clinical trials
- Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea (PHASE3)
- Comparison of Oral Dydrogesterone and Vaginal Progesterone in Menopausal Hormone Therapy (NA)
- Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency (PHASE3)
- Artificial Cycle With or Without GnRH Agonist Pre-treatment for Frozen Embryo Transfer in Adenomyosis Patients (NA)
- Impact Of FET Preparation Protocol On Endometrial Peristalsis: A Prospective Cohort Study
- A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) (PHASE2)
- Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer
- A Prospective Multicenter Observational Real-world Study of Retained Products of Conception
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Estradiol + Progesterone CI brief — competitive landscape report
- Estradiol + Progesterone updates RSS · CI watch RSS
- Productos Científicos S. A. de C. V. portfolio CI
Frequently asked questions about Estradiol + Progesterone
What is Estradiol + Progesterone?
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Related
- Drug class: All Hormone replacement therapy / Oral contraceptive drugs
- Target: All drugs targeting Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ), Progesterone receptor (PR)
- Manufacturer: Productos Científicos S. A. de C. V. — full pipeline
- Therapeutic area: All drugs in Endocrinology / Gynecology
- Indication: Drugs for Menopausal symptom relief (hot flashes, night sweats, vaginal dryness)
- Indication: Drugs for Contraception
- Indication: Drugs for Hormone replacement therapy in postmenopausal women
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing