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Luteal support with estrogen + progesterone
Estrogen and progesterone supplementation during the luteal phase supports endometrial development and maintains pregnancy viability in assisted reproductive cycles.
Estrogen and progesterone supplementation during the luteal phase supports endometrial development and maintains pregnancy viability in assisted reproductive cycles. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Endometrial preparation and pregnancy support in IVF and embryo transfer.
At a glance
| Generic name | Luteal support with estrogen + progesterone |
|---|---|
| Sponsor | Rabin Medical Center |
| Drug class | Hormone replacement therapy |
| Target | Progesterone receptor (PR) and estrogen receptor (ER) |
| Modality | Small molecule |
| Therapeutic area | Reproductive Medicine / Fertility |
| Phase | FDA-approved |
Mechanism of action
Luteal support replaces or augments the corpus luteum's natural hormone production after ovulation induction or egg retrieval. Progesterone prepares and maintains the endometrium for embryo implantation, while estrogen enhances endometrial receptivity and blood flow. This combination is used to optimize uterine conditions during the critical window following embryo transfer in in vitro fertilization (IVF) and other fertility treatments.
Approved indications
- Luteal phase support in assisted reproductive technology (ART) cycles
- Endometrial preparation and pregnancy support in IVF and embryo transfer
Common side effects
- Breast tenderness
- Bloating
- Headache
- Mood changes
- Vaginal bleeding or spotting
Key clinical trials
- Smoking Cessation and Menstrual Cycle Phase (PHASE4)
- FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles (NA)
- IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women (NA)
- Natural Cycle vs Programmed Cycle Frozen Embryo Transfer (NA)
- Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation
- Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes (NA)
- Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer (NA)
- Dual Ovarian Stimulation (DUOSTIM) for Poor Ovarian Responders (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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