{"id":"luteal-support-with-estrogen-progesterone","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Vaginal bleeding or spotting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Luteal support replaces or augments the corpus luteum's natural hormone production after ovulation induction or egg retrieval. Progesterone prepares and maintains the endometrium for embryo implantation, while estrogen enhances endometrial receptivity and blood flow. This combination is used to optimize uterine conditions during the critical window following embryo transfer in in vitro fertilization (IVF) and other fertility treatments.","oneSentence":"Estrogen and progesterone supplementation during the luteal phase supports endometrial development and maintains pregnancy viability in assisted reproductive cycles.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:42.158Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART) cycles"},{"name":"Endometrial preparation and pregnancy support in IVF and embryo transfer"}]},"trialDetails":[{"nctId":"NCT05515354","phase":"PHASE4","title":"Smoking Cessation and Menstrual Cycle Phase","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2022-11-30","conditions":"Nicotine Dependence, Tobacco Smoking, Smoking Cessation","enrollment":1200},{"nctId":"NCT07425990","phase":"NA","title":"FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles","status":"NOT_YET_RECRUITING","sponsor":"University of Novi Sad","startDate":"2026-02","conditions":"Infertility Female, Frozen Embryo Transfer (FET)","enrollment":120},{"nctId":"NCT07171970","phase":"NA","title":"IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women","status":"RECRUITING","sponsor":"Mỹ Đức Hospital","startDate":"2025-09-22","conditions":"Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer","enrollment":600},{"nctId":"NCT05716139","phase":"NA","title":"Natural Cycle vs Programmed Cycle Frozen Embryo Transfer","status":"TERMINATED","sponsor":"Indira IVF Hospital Pvt Ltd","startDate":"2023-07-15","conditions":"Infertility, Frozen Embryo Transfer, Preeclampsia and Eclampsia","enrollment":172},{"nctId":"NCT06280560","phase":"","title":"Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation","status":"RECRUITING","sponsor":"Fundación IVI","startDate":"2024-02-01","conditions":"Endometrial Receptivity","enrollment":60},{"nctId":"NCT06679491","phase":"NA","title":"Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes","status":"RECRUITING","sponsor":"Universite de La Reunion","startDate":"2024-11-01","conditions":"Menstrual Cycle, Resistance Training, Neuromuscular Function","enrollment":60},{"nctId":"NCT04092829","phase":"NA","title":"Impact of Corpus Luteum Presence or Absence in the Incidence of Preeclampsia After Frozen Embryo Transfer","status":"TERMINATED","sponsor":"Instituto Valenciano de Infertilidad, IVI VALENCIA","startDate":"2019-09-16","conditions":"Pre-Eclampsia, Frozen Embryo Transfer","enrollment":591},{"nctId":"NCT03803228","phase":"PHASE3","title":"Dual Ovarian Stimulation (DUOSTIM) for Poor Ovarian Responders","status":"COMPLETED","sponsor":"Centre Hospitalier Intercommunal Creteil","startDate":"2018-09-03","conditions":"Fertility Disorders","enrollment":88},{"nctId":"NCT04797338","phase":"PHASE4","title":"Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders","status":"UNKNOWN","sponsor":"Assaf-Harofeh Medical Center","startDate":"2017-12-29","conditions":"Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome","enrollment":100},{"nctId":"NCT04013438","phase":"PHASE3","title":"Luteal Phase Support During Frozen Embryo Transfer Cycle","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2017-11-01","conditions":"Infertility, Female, Frozen Embryo Transfer","enrollment":60},{"nctId":"NCT03832894","phase":"PHASE3","title":"Oestradiol Supplementation in Luteal Long Agonist Fresh In Vitro Fertilization/Intra Cytoplasmic Sperm Injection ( IVF/ICSI) Cycle .","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2018-12-01","conditions":"Infertility","enrollment":2},{"nctId":"NCT03773263","phase":"PHASE3","title":"New Application of Sequential in Vitro Muturation System for Infertility Patients With Polycystic Ovary Syndrome","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2018-12","conditions":"Polycystic Ovary Syndrome, Infertility","enrollment":300},{"nctId":"NCT02620124","phase":"PHASE4","title":"GnRH Agonist as Luteal Support in FET Cycles","status":"COMPLETED","sponsor":"Turku University Hospital","startDate":"2013-05","conditions":"Infertility","enrollment":100},{"nctId":"NCT01204840","phase":"PHASE2","title":"Growth Hormone for Poor Responders in in Vitro Fertilization (IVF)","status":"COMPLETED","sponsor":"Ottawa Fertility Centre","startDate":"2010-09","conditions":"Infertility, Poor Ovarian Reserve","enrollment":38},{"nctId":"NCT01595334","phase":"NA","title":"Study on Influence of Leutinizing Hormone (LH) on Oocyte Maturity","status":"UNKNOWN","sponsor":"Southern Cross Fertility Centre","startDate":"2012-04","conditions":"Infertility","enrollment":300},{"nctId":"NCT01367912","phase":"NA","title":"Timing of Estrogen Support During the Luteal Phase of in Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycle","status":"COMPLETED","sponsor":"Zekai Tahir Burak Women's Health Research and Education Hospital","startDate":"2008-02","conditions":"Infertility","enrollment":301},{"nctId":"NCT01237535","phase":"PHASE4","title":"Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates","status":"UNKNOWN","sponsor":"Rabin Medical Center","startDate":"2011-11","conditions":"Unexplained Infertility, Mild Male Factor","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":54,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Luteal support with estrogen + progesterone","genericName":"Luteal support with estrogen + progesterone","companyName":"Rabin Medical Center","companyId":"rabin-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estrogen and progesterone supplementation during the luteal phase supports endometrial development and maintains pregnancy viability in assisted reproductive cycles. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Endometrial preparation and pregnancy support in IVF and embryo transfer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}