Exparel + Bupivacaine — Competitive Intelligence Brief

Exparel + Bupivacaine (Exparel + Bupivacaine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic (liposomal formulation). Area: Anesthesia / Pain Management.

marketed Local anesthetic (liposomal formulation) Voltage-gated sodium channels Anesthesia / Pain Management Small molecule

Target snapshot

Exparel + Bupivacaine (Exparel + Bupivacaine) — Pacira Pharmaceuticals, Inc. Exparel is a liposomal formulation of bupivacaine that provides prolonged local anesthetic effect by slowly releasing bupivacaine from lipid vesicles at the injection site.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Exparel + Bupivacaine TARGET	Exparel + Bupivacaine	Pacira Pharmaceuticals, Inc	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Marcaine Injectable Product	Marcaine Injectable Product	University of California, Davis	marketed	Local anesthetic	Voltage-gated sodium channels
zonisamide high dose group	zonisamide high dose group	Eisai Korea Inc.	marketed	Sulfonamide anticonvulsant	Voltage-gated sodium channels, T-type calcium channels, GABA enhancement
Dexamethasone+ Bupivacaine	Dexamethasone+ Bupivacaine	Ain Shams University	marketed	Corticosteroid + Local anesthetic combination	Glucocorticoid receptor (dexamethasone); Voltage-gated sodium channels (bupivacaine)
Bupivacaine Liposomes(BL)	Bupivacaine Liposomes(BL)	Huazhong University of Science and Technology	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Suzetrigine (SUZ)	Suzetrigine (SUZ)	Vertex Pharmaceuticals Incorporated	marketed	Selective sodium channel inhibitor	Voltage-gated sodium channels (Nav)
Scalp block with 0.5% plain Marcaine	Scalp block with 0.5% plain Marcaine	Chiang Mai University	marketed	Local anesthetic (amide)	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic (liposomal formulation) class)

1. Pacira Pharmaceuticals, Inc · 4 drugs in this class
2. Huazhong University of Science and Technology · 1 drug in this class
3. Maimonides Medical Center · 1 drug in this class
4. The Cleveland Clinic · 1 drug in this class
5. The Cooper Health System · 1 drug in this class
6. The University of Texas Health Science Center, Houston · 1 drug in this class
7. Tianjin Medical University General Hospital · 1 drug in this class
8. University of California, Davis · 1 drug in this class
9. Catherine Vandepitte, M.D. · 1 drug in this class
10. Wake Forest University Health Sciences · 1 drug in this class