Who are Dexchlorpheniramine 1% lotion's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Atarax (Hydroxyzine), diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan, Morphine-Promethazine, Benadryl demand, Diphenhydramine 5%, fexofenadine HCl.

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Last reviewed 2026-05-16 · How we verify

Dexchlorpheniramine 1% lotion — Competitive Intelligence Brief

Dexchlorpheniramine 1% lotion (Dexchlorpheniramine 1% lotion) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: H1-receptor antagonist (first-generation antihistamine). Area: Dermatology / Allergy.

phase 3 H1-receptor antagonist (first-generation antihistamine) H1 histamine receptor Dermatology / Allergy Small molecule Live · refreshed every 30 min

Target snapshot

Dexchlorpheniramine 1% lotion (Dexchlorpheniramine 1% lotion) — Mantecorp Industria Quimica e Farmaceutica Ltd.. Dexchlorpheniramine is a first-generation H1-receptor antagonist that blocks histamine binding to reduce allergic and inflammatory responses in the skin.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Dexchlorpheniramine 1% lotion TARGET	Dexchlorpheniramine 1% lotion	Mantecorp Industria Quimica e Farmaceutica Ltd.	phase 3	H1-receptor antagonist (first-generation antihistamine)	H1 histamine receptor
Atarax (Hydroxyzine)	Atarax (Hydroxyzine)	University Hospital, Toulouse	marketed	First-generation H1 antihistamine	H1 histamine receptor
diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan	Montefiore Medical Center	marketed	Combination cold/cough/allergy remedy	H1 histamine receptor (diphenhydramine); alpha-1 adrenergic receptor (phenylephrine); NMDA receptor and sigma-1 receptor (dextromethorphan)
Morphine-Promethazine	Morphine-Promethazine	Tel-Aviv Sourasky Medical Center	marketed	Opioid analgesic combination	Mu-opioid receptor (morphine); H1 histamine receptor (promethazine)
Benadryl demand	Benadryl demand	University of Pennsylvania	marketed	First-generation H1 antihistamine	H1 histamine receptor
Diphenhydramine 5%	Diphenhydramine 5%	Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology	marketed	H1 receptor antagonist (first-generation antihistamine)	H1 histamine receptor
fexofenadine HCl	fexofenadine HCl	Sanofi	marketed	Second-generation H1-receptor antagonist (non-sedating antihistamine)	H1 histamine receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (H1-receptor antagonist (first-generation antihistamine) class)

Mantecorp Industria Quimica e Farmaceutica Ltd. · 2 drugs in this class

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Cite this brief

Drug Landscape (2026). Dexchlorpheniramine 1% lotion — Competitive Intelligence Brief. https://druglandscape.com/ci/dexchlorpheniramine-1-lotion. Accessed 2026-05-16.

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