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Diphenhydramine 5%

Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology · FDA-approved active Small molecule

Diphenhydramine 5% is a H1 receptor antagonist (first-generation antihistamine) Small molecule drug developed by Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology. It is currently FDA-approved for Allergic reactions and urticaria, Pruritus (itching), Allergic rhinitis.

Diphenhydramine is a first-generation antihistamine that blocks H1 histamine receptors to reduce allergic and inflammatory responses.

Diphenhydramine is a first-generation antihistamine that blocks H1 histamine receptors to reduce allergic and inflammatory responses. Used for Allergic reactions and urticaria, Pruritus (itching), Allergic rhinitis.

At a glance

Generic nameDiphenhydramine 5%
SponsorFederal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology
Drug classH1 receptor antagonist (first-generation antihistamine)
TargetH1 histamine receptor
ModalitySmall molecule
Therapeutic areaAllergy/Immunology
PhaseFDA-approved

Mechanism of action

Diphenhydramine competitively antagonizes H1 histamine receptors on various tissues, preventing histamine-mediated effects such as itching, urticaria, and allergic reactions. As a first-generation antihistamine, it crosses the blood-brain barrier and also possesses anticholinergic and sedating properties due to central nervous system penetration.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Diphenhydramine 5%

What is Diphenhydramine 5%?

Diphenhydramine 5% is a H1 receptor antagonist (first-generation antihistamine) drug developed by Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology, indicated for Allergic reactions and urticaria, Pruritus (itching), Allergic rhinitis.

How does Diphenhydramine 5% work?

Diphenhydramine is a first-generation antihistamine that blocks H1 histamine receptors to reduce allergic and inflammatory responses.

What is Diphenhydramine 5% used for?

Diphenhydramine 5% is indicated for Allergic reactions and urticaria, Pruritus (itching), Allergic rhinitis, Motion sickness and nausea.

Who makes Diphenhydramine 5%?

Diphenhydramine 5% is developed and marketed by Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology (see full Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology pipeline at /company/federal-state-budgetary-scientific-institution-research-institute-of-fundamental).

What drug class is Diphenhydramine 5% in?

Diphenhydramine 5% belongs to the H1 receptor antagonist (first-generation antihistamine) class. See all H1 receptor antagonist (first-generation antihistamine) drugs at /class/h1-receptor-antagonist-first-generation-antihistamine.

What development phase is Diphenhydramine 5% in?

Diphenhydramine 5% is FDA-approved (marketed).

What are the side effects of Diphenhydramine 5%?

Common side effects of Diphenhydramine 5% include Drowsiness/sedation, Dry mouth, Dizziness, Anticholinergic effects (urinary retention, constipation).

What does Diphenhydramine 5% target?

Diphenhydramine 5% targets H1 histamine receptor and is a H1 receptor antagonist (first-generation antihistamine).

Related

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing