Who are Cyclosporins/Tacrolimus's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Sandimmune, CYCLOSPORINE, Tacrolimus and Everolimus, Tacrolimus, Accord, Combination of pimecrolimus and fluticasone, Prograf (Tacrolimus).

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Last reviewed 2026-05-17 · How we verify

Cyclosporins/Tacrolimus — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cyclosporins/Tacrolimus (Cyclosporins/Tacrolimus) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Calcineurin inhibitor. Area: Immunology.

marketed Calcineurin inhibitor Calcineurin Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Cyclosporins/Tacrolimus (Cyclosporins/Tacrolimus) — University of Minnesota. Cyclosporins and tacrolimus suppress the immune system by inhibiting calcineurin, a key enzyme required for T-cell activation and cytokine production.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Cyclosporins/Tacrolimus TARGET	Cyclosporins/Tacrolimus	University of Minnesota	marketed	Calcineurin inhibitor	Calcineurin
Sandimmune	cyclosporine	Novartis AG (originally Sandoz)	marketed	Calcineurin inhibitor (immunosuppressant)	Calcineurin subunit B type 1, Canalicular multispecific organic anion transporter 1, Canalicular multispecific organic anion transporter 2	1983-11-14
CYCLOSPORINE	CYCLOSPORINE		marketed	Calcineurin Inhibitor Immunosuppressant [EPC]	calcineurin	1983-01-01
Tacrolimus and Everolimus	Tacrolimus and Everolimus	Chang Gung Memorial Hospital	marketed	Immunosuppressant (calcineurin inhibitor and mTOR inhibitor combination)	Calcineurin (tacrolimus) and mTOR (everolimus)
Tacrolimus, Accord	Tacrolimus, Accord	University of Cincinnati	marketed	Calcineurin inhibitor	Calcineurin (via FKBP12 binding)
Combination of pimecrolimus and fluticasone	Combination of pimecrolimus and fluticasone	Children's Hospital of Philadelphia	marketed	Topical immunosuppressant and corticosteroid combination	Calcineurin (pimecrolimus); glucocorticoid receptor (fluticasone)
Prograf (Tacrolimus)	Prograf (Tacrolimus)	East Carolina University	marketed	Calcineurin inhibitor	Calcineurin (via FKBP12 binding)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-11-03 — Sandimmune · 8298568 · Formulation · US
2029-06-02 — Sandimmune · 9132071 · Formulation · US
2030-12-13 — Sandimmune · 8614178 · Formulation · US
2031-02-25 — Sandimmune · 8292129 · Formulation · US
2032-04-16 — Sandimmune · 8561859 · Formulation · US
2033-08-23 — Sandimmune · 8980839 · Formulation · US
2033-08-23 — Sandimmune · 10441630 · Formulation · US
2033-08-23 — Sandimmune · 9937225 · Formulation · US
2034-02-07 — Sandimmune · 9676525 · Formulation · US
2034-05-11 — Sandimmune · 9669974 · Formulation · US
2036-09-29 — Sandimmune · 12496326 · Method of Use · US
2037-02-28 — Sandimmune · 11951153 · Method of Use · US
2037-02-28 — Sandimmune · 10918694 · Formulation · US
2037-09-22 — Sandimmune · 10813976 · Formulation · US
2038-11-20 — Sandimmune · 11154513 · Formulation · US
2039-10-11 — Sandimmune · 11413323 · Method of Use · US
2042-04-01 — Sandimmune · 12059449 · Formulation · US

Sponsor landscape (Calcineurin inhibitor class)

Novartis · 4 drugs in this class
Astellas Pharma Inc · 4 drugs in this class
Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · 4 drugs in this class
University of Cincinnati · 3 drugs in this class
Allergan · 3 drugs in this class
Astellas Pharma China, Inc. · 3 drugs in this class
Novaliq GmbH · 3 drugs in this class
Hoffmann-La Roche · 3 drugs in this class
LEO Pharma · 3 drugs in this class
Santen SAS · 3 drugs in this class

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Cite this brief

Drug Landscape (2026). Cyclosporins/Tacrolimus — Competitive Intelligence Brief. https://druglandscape.com/ci/cyclosporins-tacrolimus. Accessed 2026-05-17.

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