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Combination of pimecrolimus and fluticasone

Children's Hospital of Philadelphia · FDA-approved active Small molecule

Combination of pimecrolimus and fluticasone is a Topical immunosuppressant and corticosteroid combination Small molecule drug developed by Children's Hospital of Philadelphia. It is currently FDA-approved for Atopic dermatitis in pediatric patients, Inflammatory skin conditions in children. Also known as: Pimecrolimus cream, fluticasone.

This combination suppresses skin inflammation by blocking T-cell activation (pimecrolimus) and reducing inflammatory mediator production (fluticasone).

This combination suppresses skin inflammation by blocking T-cell activation (pimecrolimus) and reducing inflammatory mediator production (fluticasone). Used for Atopic dermatitis in pediatric patients, Inflammatory skin conditions in children.

At a glance

Generic nameCombination of pimecrolimus and fluticasone
Also known asPimecrolimus cream, fluticasone
SponsorChildren's Hospital of Philadelphia
Drug classTopical immunosuppressant and corticosteroid combination
TargetCalcineurin (pimecrolimus); glucocorticoid receptor (fluticasone)
ModalitySmall molecule
Therapeutic areaDermatology/Immunology
PhaseFDA-approved

Mechanism of action

Pimecrolimus is a calcineurin inhibitor that prevents T-cell proliferation and cytokine release, while fluticasone is a topical corticosteroid that reduces inflammatory responses. Together, they provide dual anti-inflammatory action for localized skin conditions, particularly in pediatric populations where steroid-sparing approaches are beneficial.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Combination of pimecrolimus and fluticasone

What is Combination of pimecrolimus and fluticasone?

Combination of pimecrolimus and fluticasone is a Topical immunosuppressant and corticosteroid combination drug developed by Children's Hospital of Philadelphia, indicated for Atopic dermatitis in pediatric patients, Inflammatory skin conditions in children.

How does Combination of pimecrolimus and fluticasone work?

This combination suppresses skin inflammation by blocking T-cell activation (pimecrolimus) and reducing inflammatory mediator production (fluticasone).

What is Combination of pimecrolimus and fluticasone used for?

Combination of pimecrolimus and fluticasone is indicated for Atopic dermatitis in pediatric patients, Inflammatory skin conditions in children.

Who makes Combination of pimecrolimus and fluticasone?

Combination of pimecrolimus and fluticasone is developed and marketed by Children's Hospital of Philadelphia (see full Children's Hospital of Philadelphia pipeline at /company/children-s-hospital-of-philadelphia).

Is Combination of pimecrolimus and fluticasone also known as anything else?

Combination of pimecrolimus and fluticasone is also known as Pimecrolimus cream, fluticasone.

What drug class is Combination of pimecrolimus and fluticasone in?

Combination of pimecrolimus and fluticasone belongs to the Topical immunosuppressant and corticosteroid combination class. See all Topical immunosuppressant and corticosteroid combination drugs at /class/topical-immunosuppressant-and-corticosteroid-combination.

What development phase is Combination of pimecrolimus and fluticasone in?

Combination of pimecrolimus and fluticasone is FDA-approved (marketed).

What are the side effects of Combination of pimecrolimus and fluticasone?

Common side effects of Combination of pimecrolimus and fluticasone include Application site burning or irritation, Skin atrophy (with prolonged corticosteroid use), Folliculitis.

What does Combination of pimecrolimus and fluticasone target?

Combination of pimecrolimus and fluticasone targets Calcineurin (pimecrolimus); glucocorticoid receptor (fluticasone) and is a Topical immunosuppressant and corticosteroid combination.

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