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NCT07535424
Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis
NA trial testing clotrimazole in Otomycosis in 60 participants. Completed in 20 October 2025.
20 October 2025
Quick facts
| Lead sponsor | Mayo Hospital Lahore |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 20 November 2024 |
| Primary completion | 20 October 2025 |
| Estimated completion | 20 October 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- clotrimazole (clotrimazole) — full drug profile →
- 2% Salicylic Acid
Conditions studied
- Otomycosis — all drugs for Otomycosis →
Sponsor
Mayo Hospital Lahore
Who can join
Adults 5 to 60, any sex, with Otomycosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Otomycosis is a fungal infection of the outer ear canal that commonly causes itching, discomfort, discharge, and a feeling of blockage in the ear. This randomized controlled study was conducted to compare two commonly used topical treatments for otomycosis: clotrimazole ear drops and 2% salicylic acid ear drops. A total of 60 patients diagnosed with otomycosis were enrolled and were randomly assigned in equal numbers to one of the two treatment groups. One group received clotrimazole drops three times daily for two weeks, while the other group received 2% salicylic acid drops at the same frequency and for the same duration. Patients were assessed at the start of treatment and again after two weeks. The main outcome measure was relief of ear blockage, which reflected improvement in canal patency after treatment. It was hypothesized that topical clotrimazole would be more effective than 2% salicylic acid in clearing ear blockage and improving short-term clinical recovery in patients with otomycosis. This study was conducted to provide evidence for selecting an effective, practical, and affordable topical treatment for routine clinical use.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07535424
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Related trials
Other trials of clotrimazole
Trials testing the same drug.
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Other recruiting trials for Otomycosis
Currently open trials in the same condition.
- NCT06530069 — Exploring the Risk Factors of Otomycosis: A Case-Control Study · recruiting
Other Mayo Hospital Lahore trials
Trials by the same sponsor.
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- NCT07144969 — Chewing Gum vs Honey in Postoperative Recovery After Ileostomy Reversal: A Study Comparing Their Effects on Bowel Functi · NA · completed
- NCT07334223 — Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal Shivering · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07535424 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Hospital Lahore
- Last refreshed: 17 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07535424.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing